Evidence map›Paper›PMID 41416940›Full record

ArticleEuropean journal of immunology2025

Augmented MHC Class I on Professional Antigen-Presenting Cells and Enhanced Cytokine Production by CD8

Shan Liu, Tharushika Jayasinghe, Daria Kamińska, Xiaoqiang Xu, Xu Ren, Yang Jiao, Ying Kong, Xiaozhen Li, Ke Li, Antony N Antoniou and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shan LiuDepartment of Endocrinology, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Tharushika JayasingheCore Research Laboratory, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Daria KamińskaInstitute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Lodz, Poland.ORCID 0000-0002-5615-0759
Xiaoqiang XuAmigene Institute, Shenzhen, Guangdong, China.
Xu RenCore Research Laboratory, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Yang JiaoDepartment of Endocrinology, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ying KongDepartment of Endocrinology, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Xiaozhen LiThe Department of Health Management, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ke LiCore Research Laboratory, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Antony N AntoniouFaculty of Life and Health Sciences, Northumbria University, Newcastle upon Tyne, UK.
Wang LiDepartment of Endocrinology, Xi'an International Medical Center Hospital, Xi'an, Shaanxi, China.
Katarzyna BłażewskaInstitute of Organic Chemistry, Lodz University of Technology, Lodz, Poland.
Edyta Gendaszewska-DarmachInstitute of Molecular and Industrial Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Lodz, Poland.
Jing XuDepartment of Endocrinology, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0009-0004-5824-0071
Malgorzata A GarstkaDepartment of Endocrinology, the Second Affiliated Hospital, School of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi, China.ORCID 0000-0003-2896-7275

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective antigen presentation by major histocompatibility complex (MHC) molecules to T cells is crucial for adaptive immunity. In type 2 diabetes mellitus (T2DM), metabolic dysregulation and chronic inflammation may impair these processes. We conducted a cross-sectional study to compare immune phenotypes between people with T2DM and healthy controls, and to correlate these findings with clinical parameters. People with T2DM exhibited augmented MHC I levels on B cells and CD14

Indexed as

Antigen-Presenting CellsCD8-Positive T-LymphocytesCytokinesDiabetes Mellitus, Type 2Histocompatibility Antigens Class IAdultAgedAntigen PresentationCross-Sectional StudiesFemaleHumansInterferon-gammaInterleukin-10MaleMiddle AgedCytokinesHistocompatibility Antigens Class IInterferon-gammaInterleukin-10CD8+ T cellshyperglycemiainflammationMHC class I moleculesprofessional antigen‐presenting cellstype 2 diabetes mellitus

Identifiers

PMID41416940
PMCPMC12716204

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.