Trial reportEuropean journal of applied physiology2026
Effects of low-carbohydrate time-restricted eating, with or without sprint interval training, on resting cardiac biomarkers in young adults: a sex-stratified randomized controlled trial.
Trial report in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- High-intensity exercise training mitigates post-exercise orthostatic hypotension in men.European journal of applied physiology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeLow-carbohydrate time-restricted eating (LCTR) and sprint interval training (SIT) independently improve cardiometabolic health, but their combined effects on cardiac-specific biomarkers remain unknown. We investigated whether LCTR, with or without SIT, affects N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) concentrations in young adults.
methodsSixty-one young adults (31 males, 30 females) were randomized to a 4-week program of LCTR alone or LCTR + SIT. All participants consumed ≤ 10% of energy from carbohydrates within an 8-hour daily window. LCTR + SIT groups additionally performed 5 weekly sessions of 10 × 6-second sprints with 9-second recovery periods. Body composition, V̇O₂max, and NT-proBNP and cTnT were assessed pre- and post-intervention. Data were analyzed using three-way mixed ANOVA with intervention (LCTR vs. LCTR + SIT) and sex as between-subjects factors, and time as within-subjects factor.
resultsBody fat decreased across all groups (range -1.2 to -2.6 kg, P < 0.05), with no significant between-group differences. Significant intervention × time interaction was observed for V̇O₂max (P = 0.003), whereas NT-proBNP showed a significant intervention × sex × time interaction (P = 0.016). Post-hoc analyses revealed that only females in the LCTR + SIT group demonstrated a significant improvement in V̇O2max (+ 17.1%, P = 0.014) and a reduction in NT-proBNP (-48%, P = 0.0005). Resting cTnT levels did not change in any group, with most values at or below detection limits.
conclusionBrief LCTR, with or without SIT, reduced body fat in both sexes. Only females in the LCTR + SIT group demonstrated reduced resting NT-proBNP. Reasons for, and implications of, this rapid and sex-mediated adaptation in NT-proBNP are worthy of further study.
Indexed as
Identifiers
41417059What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.