Evidence map›Paper›PMID 41417064›Full record

ArticleEuropean journal of applied physiology2026

Exogenous lactate infusion enhanced VMH neuroplasticity and visceral fat reduction via PGC-1α-ERα pathway in female rats.

Shuai Tian, Jing Han, Zhaomin Zhang, Jinchan Du, Wei Chen, Yang Liu

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Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuai Tian *School of Physical Education, Hebei Normal University, Shijiazhuang, China.ORCID http://orcid.org/0009-0009-9775-0214
Jing Han *School of Physical Education, Hebei Normal University, Shijiazhuang, China.
Zhaomin ZhangSchool of Physical Education, Hebei Normal University, Shijiazhuang, China.
Jinchan DuSchool of Physical Education, Hebei Normal University, Shijiazhuang, China.
Wei ChenSchool of Physical Education, Hebei Normal University, Shijiazhuang, China.
Yang LiuSchool of Physical Education, Hebei Normal University, Shijiazhuang, China. liuyang1982@hebtu.edu.cn.ORCID http://orcid.org/0000-0002-2113-7490

Funding

Hebei Normal University No. XCXZZBC 202553Natural Science Foundation of Hebei Province No. C2024205024
6 · The paper itself

Abstract

High-intensity exercise promotes visceral adipose tissue (VAT) breakdown in females via the hypothalamic ERα pathway, and exogenous lactate infusion combined with aerobic training (AT) mimics this effect. However, whether lactate administration can independently mediate hypothalamic plasticity and VAT catabolism as a standalone nutritional strategy remains unexplored. Firstly, using a two-factor design (Lactate × AT) in female SD rats, we showed that long-term exogenous lactate infusion independently induced co-expression of Estrogen receptor α (ERα) and Brain-derived neurotrophic factor (BDNF) in the ventromedial hypothalamus (VMH) and elevated local field potential spectral power in specific bands. These neural adaptations were accompanied by increased resting metabolic rate, enhanced fat oxidation, and enhanced lipolysis, thereby preventing excessive VAT accumulation induced by a high-fat diet. Furthermore, pharmacological inhibition confirmed that Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α (PGC-1α) acts as a co-upstream signal of ERα and BDNF mediating this process. Our findings reveal that standalone lactate administration induces functional plasticity and metabolic reprogramming through the VMH PGC-1α-ERα pathway, independent of exercise, and effectively suppresses pathological VAT accumulation in female rats. This study identifies potential nutritional interventions and mechanistic targets for preventing female-centered obesity.

Indexed as

Estrogen Receptor alphaIntra-Abdominal FatLactic AcidNeuronal PlasticityPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaVentromedial Hypothalamic NucleusAnimalsBrain-Derived Neurotrophic FactorFemalePhysical Conditioning, AnimalRatsRats, Sprague-DawleySignal TransductionBrain-Derived Neurotrophic FactorEstrogen Receptor alphaLactic AcidPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, ratERαFemaleLactateVisceral adipose tissueVMH

Identifiers

PMID41417064

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.