Trial reportEuropean journal of nutrition2025
Ancient grain flour consumption as a novel therapeutic approach for irritable bowel syndrome.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modulation of Dietary 5-Hydroxymethylfurfural-Induced Intestinal Epithelial Stress by Blueberry Polyphenols.International journal of molecular sciences · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClimate change has revived interest in ancient grains for their sustainability and nutritional value. Less processed and more resilient than modern cereals, they have a lower environmental impact. Grains like Triticum monococcum and Jermano wheat may benefit IBS patients due to their better digestibility. This study explores their use in functional pasta to manage IBS symptoms.
methodsForty-two IBS patients followed a 4-week low-FODMAP diet with either traditional gluten-free pasta or functional pasta (FP) made from emmer and rye flour. IBS symptoms were assessed using the IBS-SSS questionnaire at baseline and after intervention. In vitro, functional pasta extract (FPE) was tested on TNF-α-induced Caco-2 and T84 cells to evaluate its effects on inflammatory and oxidative stress markers.
resultsPatients consuming FP showed a significant reduction in IBS-SSS scores compared to the control group (- 153 ± 124 vs. - 83 ± 85, p = 0.044). Additionally, 83% of those on FP reported a clinically significant reduction in symptom severity (IBS-SSS score ≥ 100) compared to 35% in the control group (p = 0.004). In Caco-2 and T84 cells, FPE has been shown to downregulate protein expression of the pErk1/2 and NF-κB signaling pathways, thereby reducing inflammatory oxidative stress markers.
conclusionThese findings suggest that consuming functional pasta made with ancient grains could enhance gut health and alleviate symptoms of IBS by reducing inflammation and oxidative stress. This innovative dietary approach offers a promising natural alternative for improving the quality of life in IBS patients.
trial registrationTrial registration ISRCTN, ISRCTN12170245 Registered 13 june 2025-Retrospectively Registered, https://doi.org/10.1186/ISRCTN12170245 .
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