Evidence map›Paper›PMID 41417237›Full record

Trial reportEuropean journal of nutrition2025

Impact of antioxidants fortified eggs consumption on eye health in individuals with mild to moderate untreated eczema: a randomized controlled trial.

Weili Hu, Shuqi Li, Xuecong Li, Amelia Shan Mei Chng, Chunjun Quek, Zhihui Chong, Chin Meng Khoo, Jung Eun Kim

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05913791 (Impact of Nutrients-fortified Egg Consumption on Eczema Condition in Individuals With Eczema), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05913791 naunknown statusnot on this map

Impact of Nutrients-fortified Egg Consumption on Eczema Condition in Individuals With Eczema

TypeinterventionalSponsorNational University of SingaporeRan2023 to 2025Enrolled41ConditionsEczema, Atopic, Inflammation, Skin, EczemaArmsNutrients-fortified egg, Regular egg
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Weili HuDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Shuqi LiDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Xuecong LiDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Amelia Shan Mei ChngDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Chunjun QuekDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Zhihui ChongDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore.
Chin Meng KhooDepartment of Endocrinology, National University Health System, Singapore, 119228, Singapore.
Jung Eun KimDepartment of Food Science and Technology, National University of Singapore, Science Drive 2, Singapore, 117543, Singapore. fstkje@nus.edu.sg.ORCID http://orcid.org/0000-0002-3912-9042

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEczema is a systemic condition associated with an increased risk of eye diseases. Xanthophylls and other antioxidants are eye-beneficial, and eggs are an excellent source of xanthophylls, often fortified to enhance their benefits. However, the effects of antioxidant-rich egg consumption on eye health in individuals with eczema have not been clinically validated. This study examined the effects of consuming regular eggs and antioxidant-fortified eggs on eye health in individuals with mild to moderate eczema via a 12 weeks, double-blind, randomized controlled trial.

methodsForty adults were randomized into two groups: the intervention group (n = 21) consumed two antioxidant-fortified eggs daily and the regular egg group (n = 19) consumed two regular eggs daily. Macular pigment optical density (MPOD), best corrected visual acuity (BCVA), contrast sensitivity (CS), photostress recovery time (PSR) and visual function questionnaire (VFQ25) were assessed every 3 weeks. Plasma levels of xanthophylls and fortified antioxidants, and nutrient intakes from the basal diet were assessed every 6 weeks.

resultsOver the 12 weeks period, significant time effects showed improvements in MPOD, CS primarily driven by the regular egg group, and PSR mainly in by the intervention group. Both groups showed increases in VFQ25 composite scores and plasma xanthophyll concentrations. However, no differences over time were observed in BCVA, plasma fortified-antioxidants concentrations, or basal diet antioxidant intakes were observed between groups.

conclusionDaily consumption of two eggs improves eye health-related parameters, while antioxidant-fortified eggs provide additional benefits in PSR. Eggs may serve as a beneficial dietary strategy for improving eye health. Trial registration: Clinicaltrials.gov: NCT05913791.

Indexed as

AntioxidantsEczemaEggsFood, FortifiedAdultContrast SensitivityDietDouble-Blind MethodFemaleHumansMacular PigmentMaleMiddle AgedVisual AcuityXanthophyllsYoung AdultAntioxidantsMacular PigmentXanthophyllsAntioxidant-fortified eggsEczemaMacular pigment optical densityMacular xanthophyllsRandomized controlled trialVisual function

Identifiers

PMID41417237

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.