Evidence map›Paper›PMID 41417455›Full record

ArticleMolecular biotechnology2026

Green Synthesis of Silver Nanoparticles Using Hypecoum pendulum L. Extract: In Vivo Anti-Hyperglycemic and In Vitro Antimicrobial Effects.

Noor Ul Huda, Mushtaq Ahmed, Saboor Badshah, Nadia Mushtaq, Rahmat Ali Khan, Haleema Saeed, Naila Sher, Noshaba Afshin, Riaz Hussain, Farhad Badshah

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Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Noor Ul HudaDepartment of Biotechnology, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Mushtaq AhmedDepartment of Biotechnology, University of Science and Technology Bannu, Bannu, KP, Pakistan. dr.mushtaq@ustb.edu.pk.
Saboor BadshahDepartment of Botany, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Nadia MushtaqDepartment of Botany, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Rahmat Ali KhanDepartment of Biotechnology, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Haleema SaeedDepartment of Allied Health Sciences, Khyber Medical University Peshawar, Peshawar, KP, Pakistan.
Naila SherDepartment of Biotechnology, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Noshaba AfshinDepartment of Botany, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Riaz HussainDepartment of Botany, University of Science and Technology Bannu, Bannu, KP, Pakistan.
Farhad BadshahShenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Livestock and Poultry Multi-Omics of MARA, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, People's Republic of China. farhadbadshah999@gmail.com.ORCID http://orcid.org/0000-0001-6971-0957

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to generate a simple and valid scheme for biosynthesis of Hypecoum pendulum L. (HP) extract-based silver nanoparticles (HP-AgNPs) and to assess their in vivo anti-hyperglycemic and in vitro antimicrobial potency. Characterization by UV spectroscopy verified the existence of HP-AgNPs at 417 nm. The functional moieties that help in the HP-AgNPs stabilization and reduction were analyzed by the FTIR technique. The face-centered cubic crystal nature of HP-AgNPs (size: 36.3 nm) was assessed using the XRD technique. Surface morphologies with predicted nanoscale size (80 nm) were confirmed by SEM examination. EDX revealed a sharp peak (3.2 keV) that confirmed Ag as a leading element (49%). Alloxan was applied to induce diabetes in female Sprague-Dawely rats (age: 1.5-2 months, body weight: 120-150 g). The 21-day treatment of diabetic rats with HP extract and HP-AgNPs resulted in a significant gain in average body weight, average organ weight, and hemoglobin level, as well as a decline in HbA1c, blood sugar, lipid, and liver profile levels in comparison to the diabetic-untreated group. HP-AgNPs showed promising antibacterial efficacy against all tested strains (Gram-positive and negative) in a positive trend with concentration. Green-synthesized HP-AgNPs also showed considerable inhibition of all tested fungal strains as compared to HP extract. The phytochemical analysis of the HP plant confirmed the phytochemicals attributed to the antimicrobial and anti-diabetic power of HP extract and HP-AgNPs. These outcomes showed that HP-AgNPs have demonstrated promising anti-diabetic and antimicrobial action than HP-extract.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsHypoglycemic AgentsMetal NanoparticlesPlant ExtractsSilverAnimalsBlood GlucoseDiabetes Mellitus, ExperimentalFemaleGreen Chemistry TechnologyMicrobial Sensitivity TestsRatsRats, Sprague-DawleyAnti-Bacterial AgentsAnti-Infective AgentsBlood GlucoseHypoglycemic AgentsPlant ExtractsSilverAntiBacterialFungalHypecoum pendulumHyperglycemic activityNanoparticlesNanotechnology

Identifiers

PMID41417455

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.