Evidence map›Paper›PMID 41417838›Full record

ArticleBioconjugate chemistry2026

Amphiphilic Polymeric Micelle Spherical Nucleic Acids (SNAs) as Drug Delivery Vehicles.

John P Cavaliere, Connor M Forsyth, Allen X Guo, Janice Kang, Kathleen H Ngo, Chad A Mirkin

Abstract read
In one paragraph

Article in Bioconjugate chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John P CavaliereDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Connor M ForsythInterdisciplinary Biological Sciences Graduate Program, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-2576-861X
Allen X GuoDepartment of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0009-0004-9995-4046
Janice KangDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0009-0007-0837-2406
Kathleen H NgoDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0009-0000-0626-1509
Chad A MirkinDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-6634-7627

Funding

Resource Development CoreU54DK137516 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Eun Ji Paige Chung, Pinelopi P. Kapitsinou · 2023 to 2026
$4.8M
Innovative Research for Cancer Nanotechnology (IRCN) for Enhancing Melanoma-specific Immune Responses by the Rational Design of Spherical Nucleic AcidsR01CA257926 · NCI · NORTHWESTERN UNIVERSITY · PI CHAD A. MIRKIN, Bin Zhang · 2022 to 2026
$2.5M
Spherical Nucleic Acid nano-architectures as first-in-class cGAS agonists for the immunotherapeutic treatment of Glioblastoma.R01CA275430 · NCI · WASHINGTON UNIVERSITY · PI MIRKIN, CHAD A., STEGH, ALEXANDER H. · 2022 to 2025
$2.3M
NCI NIH HHS R01 CA257926NCI NIH HHS R01 CA275430NIDDK NIH HHS U54 DK137516
6 · The paper itself

Abstract

This work describes the synthesis and characterization of a new class of spherical nucleic acid (SNA) derived from amphiphilic polymeric micelles (APM-SNA) for the delivery of hydrophobic drugs. Core structures are assembled from amphiphilic copolymers comprising a hydrophobic block (made from hydroxypropyl methacrylate and methacrylates bearing

Indexed as

Drug CarriersDrug Delivery SystemsMicellesNucleic AcidsPolymersSurface-Active AgentsHumansHydrophobic and Hydrophilic InteractionsDrug CarriersMicellesNucleic AcidsPolymersSurface-Active Agents

Identifiers

PMID41417838
PMCPMC13051403

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.