ArticlePoultry science2026
Digestibility and transcriptomic profiling of kidney, pancreas, follicle, and uterus in laying hens supplemented with phytogenic feed additive.
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Limited incremental response to routine phytase supplementation in Hy-Line Brown laying hens fed mineral-adequate diets.Poultry science · 2026Article
- Effects of Dietary Supplementation with α-Mangostin on Oviduct Inflammation and Eggshell Quality in Aging Laying Hens.Animals : an open access journal from MDPI · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phytogenic feed additives in poultry demonstrate phenotypic improvements and potentially possess humoral significance for organ systems involved in egg production, digestion, and excretion, warranting further investigation into their mechanisms of action. These additives contain a wide array of active ingredients with antimicrobial, immunomodulatory, and antioxidant properties, positioning them as a promising alternative to in-feed antibiotics for enhancing poultry performance and welfare. This study investigates how a phytogenic feed supplement based mainly on essential oils of thyme and star anise with quillaja bark influences reproductive and nutrient-utilizing tissues and nutrient bioavailability in laying hens. A four-week trial with Lohmann Brown hens aged 68 weeks was conducted using diets with or without 150 mg/kg phytogenic supplement to assess performance (n = 96), egg quality (n = 96), nutrient digestibility (n = 24), and gene expression in pancreas, kidney, uterus, and follicles (n = 20 per tissue). Supplemented laying hens showed a significant increase of 3.84 % (p = 0.001) in the apparent ileal digestibility of crude protein and trends for improved egg weights (p = 0.053) and feed-to-egg mass ratio (p = 0.079) compared to control-fed hens. Complementary RNA sequencing analyses revealed differentially expressed genes (adjusted p-value < 0.05) with antimicrobial properties (pancreas, follicles) and an influence on bio-mineralization processes (uterus). Results suggest improved cleavage of carbohydrates, peptides, and lipids in the follicle, indicating improved nutrient utilisation for the developing embryo. Consequently, the implementation of phytogenics improves nutrient digestibility of laying hens and promotes resource reallocation in the hen towards the immune system and nutrient availability in eggs, potentially benefiting both in-ovo development and egg quality. A targeted phytogenic feed supplement can enhance the expression of antibacterial proteins involved in innate immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.