ArticleEnvironment international2026
PFOS-induced black liver and hepatic aging in mice: A new paradigm in environmental hepatotoxicology.
Article in Environment international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- PFOS exposure is linked to immune-metabolic disruption in MASLD: integrated population, computational, and experimental evidence.Molecular diversity · 2026Article
- Article
- Integrated analysis of autophagy and ferroptosis mediating aristolochic acid A-induced nephrotoxicity via transcriptome and m6A epigenetic transcriptome in HK-2 cells.Frontiers in genetics · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Perfluorooctanesulfonic acid (PFOS), a persistent environmental contaminant still imported and widely used in industrial and consumer products, poses poorly defined risks under chronic occupational exposure, with limited research on its role in environmental liver aging. Here, we identify previously unrecognized hepatotoxicity of PFOS in mice exposed to an occupationally relevant dose (10 mg/kg) over subacute (25-day) and chronic (105-day) periods. While both exposures induced mild metabolic-associated steatotic liver disease (MASLD) without fibrosis, only chronic exposure produced a distinct "black liver" phenotype marked by pigmentation, hepatic atrophy, and aging. The black liver discoloration was associated with hepatic congestion and the consequential blood stasis likely contributed to the darkened liver appearance. PFOS also disrupted bile canaliculi by downregulating ZO-1 and mislocalizing BSEP and MRP2, resulting in cholestasis mimicking the Dubin-Johnson Syndrome which displays black liver appearance. Most notably, PFOS activated aging hallmarks, including oxidative stress (superoxide, 4-HNE), genomic instability (γH2AX, 8-oxo-dG), cellular senescence (SA-β-Gal, p21
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.