ReviewAmerican journal of physiology. Lung cellular and molecular physiology2026
The role of carotid bodies in opioid-induced respiratory depression.
Review in American journal of physiology. Lung cellular and molecular physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Enhanced In Vivo Antinociceptive Activity and GC-MS Chemical Profiling of In Vitro-GrownMolecules (Basel, Switzerland) · 2026Article
- Acute buprenorphine exposure depresses neonatal respiratory chemoreflexes in the presence or absence of naloxone.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Interest in respiratory stimulants has increased over the years. Research have intensified after the introduction of opioids that cause respiratory depression. In the most recent years, the indiscriminate consumption of opioids has generated concern and, consequently, there has been a growing number of studies focusing on respiratory stimulants that can mitigate opioid-induced respiratory depression (OIRD) without inducing withdrawal and identifying the molecular mechanisms. Carotid bodies (CBs) are polymodal sensors capable of detecting and responding to a wide variety of chemical stimuli, such as hypoxia, hypercapnia, hypoglycemia, hyperinsulinemia, and hyperleptinemia, among others. CBs have emerged as a potential therapeutic target to alleviate or eliminate OIRD. In this review, we present the most recent data on the mechanisms by which CBs may counteract OIRD. We also discuss whether CBs' stimulation may be a therapeutic target to relieve OIRD without affecting analgesia.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.