Evidence map›Paper›PMID 41419571›Full record

ArticleNature cell biology2026

Autophagy-regulated mitochondrial inheritance controls early CD8

Mariana Borsa, Ana Victoria Lechuga-Vieco, Amir H Kayvanjoo, Edward Jenkins, Yavuz Yazicioglu, Ewoud B Compeer, Felix C Richter, Simon Rapp, Robert Mitchell, Tom Youdale and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mariana BorsaKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. mariana.borsa@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0003-1519-2597
Ana Victoria Lechuga-ViecoKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5546-9752
Amir H KayvanjooMax-Delbrück-Center for Molecular Medicine, Berlin, Germany.ORCID http://orcid.org/0000-0003-1315-8336
Edward JenkinsKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Yavuz YaziciogluKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Ewoud B CompeerKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-3050-7633
Felix C RichterKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Simon RappKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5141-0611
Robert MitchellKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Tom YoudaleDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.
Hien BuiFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Emilia KuuluvainenFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
Michael L DustinKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-4983-6389
Linda V SinclairDivision of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0003-1248-7189
Pekka KatajistoFaculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3033-4189
Anna Katharina SimonKennedy Institute of Rheumatology, University of Oxford, Oxford, UK. katja.simon@mdc-berlin.de.ORCID http://orcid.org/0000-0002-4077-7995

Funding

EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) ERC-2021-SyG_951329EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) Marie Sklodowska-Curie 893676European Molecular Biology Organization (EMBO) ALTF1155-2019Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) Early Postdoc.Mobility P2EZP3_188074Wellcome TrustWellcome Trust (Wellcome) 203803/Z16/ZWellcome Trust (Wellcome) 220452/Z/20/ZWellcome Trust (Wellcome) 220784/Z/20/Z
6 · The paper itself

Abstract

T cell immunity deteriorates with age, accompanied by a decline in autophagy and asymmetric cell division. Here we show that autophagy regulates mitochondrial inheritance in CD8

Indexed as

AutophagyCD8-Positive T-LymphocytesMitochondriaAnimalsCell DifferentiationCell LineageImmunologic MemoryMiceMice, Inbred C57BLMice, Knockout

Identifiers

PMID41419571
PMCPMC12807857

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.