Evidence map›Paper›PMID 41419624›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Subtype specific immune-metabolic reprogramming in preeclampsia revealed by multiomics and serum biomarkers.

Yixuan Chen, Linlin Wu, Dongni Huang, Xiaoxia Wu, Kan Liu, Bo Sun, Jinying Yang, Baozhen Zhang, Zijun Ouyang, Cuilian Zhang and 2 more

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Insights into the maternal-fetal interface from spatial multi-omics.Frontiers in cell and developmental biology · 2026
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yixuan Chen *Department of Reproductive Medical Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan, China.
Linlin Wu *Department of Obstetrics, The Eight Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Dongni Huang *Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Xiaoxia WuDepartment of Obstetrics, Shenzhen Maternity & Child Healthcare Hospital, Guangdong, China.
Kan LiuDepartment of Obstetrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan, China.
Bo SunDepartment of Obstetrics, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, China.
Jinying YangDepartment of Obstetrics, Longgang Maternity and Child Clinical Institute, Shenzhen, China.
Baozhen ZhangWomen and Children's Hospital of Chongqing Medical University, Chongqing, China.
Zijun OuyangSchool of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China.
Cuilian ZhangDepartment of Reproductive Medical Center, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital of Henan University, Zhengzhou, Henan, China. luckyzcl@qq.com.
Lunbo TanWomen and Children's Hospital of Chongqing Medical University, Chongqing, China. lunbo.tan@outlook.com.
Jianmin NiuDepartment of Obstetrics, Shenzhen Maternity & Child Healthcare Hospital, Guangdong, China. njianmin@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preeclampsia comprises early-onset (EOPE) and late-onset (LOPE) subtypes with distinct etiologies, placental pathology, and severity, but cellular/metabolic drivers and early biomarkers remain unclear. We integrated placental single-cell RNA-seq, spatial transcriptomics, and spatial metabolomics from EOPE, LOPE, and matched controls, and performed maternal serum metabolomics in a prospective cohort of 199 pregnancies. The scRNA-seq identified 14 cell types; Hofbauer cells and trophoblasts resolved into 7 and 3 subclusters. EOPE placentas showed increased macrophages and extravillous trophoblasts, reduced oxygen-transporting Hofbauer subtypes (HB_1, HB_6), and trophoblasts with heightened HIF-1, VEGF, and IGF signaling. LOPE preserved cellular composition but exhibited stronger inflammatory transcriptional programs. Spatial analyses indicated disrupted oxygen transport in EOPE and perturbed interferon-γ signaling and exosome secretion in LOPE. Metabolically, trophoblasts and Hofbauer cells displayed subtype-specific lipid-transport defects and mitochondrial dysfunction. Three early-pregnancy serum metabolites-phosphatidylcholine PC(22:5/0:0), 3-hydroxybutyric acid, and L-allothreonine-robustly predicted EOPE (AUC > 0.85). This study delineates preeclampsia as a spectrum of placental immune-metabolic disorders. Hofbauer cells and trophoblasts undergo subtype-specific transcriptional and metabolic remodeling in EOPE vs LOPE. Multi-omics-guided, noninvasive biomarkers enable early EOPE risk prediction, informing timely detection and intervention.

Indexed as

PlacentaPre-EclampsiaAdultBiomarkersFemaleHumansMetabolic ReprogrammingMetabolomicsMultiomicsPregnancyTrophoblastsBiomarkersDigital hypertensionHofbauer cellsImmune-metabolic remodelingMorning hypertensionPreeclampsia

Identifiers

PMID41419624
PMCPMC12960252

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.