ArticleThe Journal of antibiotics2026
High-level polymyxin B resistance and underlying mechanism in a multidrug-resistant Acinetobacter strain isolated from the marine plastisphere.
Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exploratory Evaluation of Susceptibility Patterns of Clinical Isolates ofAntibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antibiotic resistance of Acinetobacter poses a serious threat to public health. Still, the antibiotic resistance features of marine Acinetobacter remain largely unexplored. Here, an Acinetobacter beijerinkii strain, named as MPE71, was isolated from the marine plastisphere. Phylogenetic analysis revealed close relationship of MPE71 with two human pathogenic strains of Acinetobacter. Minimum inhibitory concentration (MIC) assays of 10 antibiotics demonstrated the multidrug-resistance of MPE71. Notably, it showed a MIC of 200 µg/mL against polymyxin B. To the best of our knowledge, this is the first report demonstrating that Acinetobacter from the marine plastisphere exhibits multidrug resistance, including high-level resistance to polymyxin B. Genomic resistance gene analysis revealed numerous multidrug efflux pump genes encoded in MPE71. The resistance mechanism was further studied using transcriptomics. Enhanced membrane biosynthesis, multidrug efflux pumps, and periplasmic protein factors largely explained the resistance of MPE71 to polymyxin B, with up-regulation of relevant genes in a dose-dependent manner. Subsequently, inhibition of the proton motive force (PMF) by carbonyl cyanide 3-chlorophenylhydrazone diminished MPE71 resistance to polymyxin B, underscoring the key role of PMF-dependent efflux pumps. This study provides new evidence for the ecological risk of antibiotic resistance in the marine plastisphere.
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Registered trials
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