ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Central amygdalar PKCδ neurons mediate fentanyl withdrawal.
Lisa M Wooldridge, Jacqueline W K Wu, Adrienne Y Jo, Morgan Zinn, Angela M Lee, Malaika Mahmood, Savanna A Cohen, Nora M McCall, Corinna S Oswell, Sophie A Rogers and 1 more
Abstract read
In one paragraphArticle in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Lisa M WooldridgeDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Adrienne Y JoDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Morgan ZinnDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Angela M LeeDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Malaika MahmoodDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Savanna A CohenDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Corinna S OswellDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sophie A RogersDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Funding
Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8MMapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4MImpact of fentanyl dependence on a parabrachio-amygdalar opioid circuitF31DA057795 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WOOLDRIDGE, LISA · 2023 to 2025
$122kU.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) F31DA057795U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA054374U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA056599
6 · The paper itselfAbstract
Aversion to opioid withdrawal is a significant barrier to achieving lasting opioid abstinence. The central amygdala (CeA), a key brain region for pain, threat-detection, autonomic engagement, and valence assignment, is active during opioid withdrawal. However, the role of molecularly distinct CeA neural populations in withdrawal remains underexplored. Here, we investigated the activity dynamics, brain-wide connectivity, and functional contribution of Protein Kinase C-delta (PKCδ)-expressing neurons in the CeA lateral capsule (CeLC
Indexed as
Analgesics, OpioidCentral Amygdaloid NucleusFentanylNeuronsProtein Kinase C-deltaSubstance Withdrawal SyndromeAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicNaloxoneNarcotic AntagonistsAnalgesics, OpioidFentanylNaloxoneNarcotic AntagonistsProtein Kinase C-delta
Identifiers
PMID41419678
PMCPMC13125285
What Socratic holds
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