Evidence map›Paper›PMID 41419687›Full record

ArticleBasic research in cardiology2026

From kidney injury to cardiac dysfunction: the central role of oxidative stress in diabetes and CKD.

Payel Sen, Theresa Sittig, Jules Hamers, Laura d'Ambrosio, Irem Ornek, Junqing Zhang, Bachuki Shashikadze, Jan B Stöckl, Marie Bachter, Susanne Bierschenk and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Basic research in cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Payel SenInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Theresa SittigInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Jules HamersInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Laura d'AmbrosioInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Irem OrnekInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Junqing ZhangInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Bachuki ShashikadzeGene Center, LMU Munich, Munich, Germany.
Jan B StöcklGene Center, LMU Munich, Munich, Germany.
Marie BachterInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Susanne BierschenkInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Simone RennerInterfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany.
Eckhard WolfInterfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICONLMU), LMU Munich, Munich, Germany.
Sebastian ClaussInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany.
Thomas FröhlichGene Center, LMU Munich, Munich, Germany.
Alexander G NickelDepartment of Translational Research, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Christoph MaackDepartment of Translational Research, Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany.
Daphne MerkusInstitute for Surgical Research, Walter Brendel Center of Experimental Medicine, University Clinic Munich, LMU Munich, Marchioninistrasse 68, 81377, Munich, Germany. daphne.merkus@med.uni-muenchen.de.ORCID 0000-0002-4852-831X

Funding

Deutsche Forschungsgemeinschaft Ma 2528/8-1Deutsche Forschungsgemeinschaft Ma 2528/9-2Deutsche Forschungsgemeinschaft project #315254108Deutsche Forschungsgemeinschaft project # 453989101Deutsche Forschungsgemeinschaft project # 505805397Deutsche Forschungsgemeinschaft SFB 1525DZD 82DZD08D03DZHK 81X2600286DZHK DZHK81Z0600207Friedrich-Baur-Stiftung Reg Nr- 28/21
6 · The paper itself

Abstract

Both diabetes mellitus (DM) and chronic kidney disease (CKD) predispose to cardiac remodeling and coronary microvascular dysfunction, which is proposed to be mediated through increased oxidative stress. To link oxidative stress and cardiac remodeling in DM and CKD, CKD was induced in genetically modified DM swine (INS

Indexed as

Oxidative StressRenal Insufficiency, ChronicVentricular Function, LeftVentricular RemodelingAnimalsDisease Models, AnimalFemaleHumansMaleMitochondria, HeartProteomicsSwineCardiac dysfunctionChronic kidney diseaseCoronary microcirculationDiabetesMitochondriaOxidative stress

Identifiers

PMID41419687
PMCPMC12804299

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.