Evidence map›Paper›PMID 41419739›Full record

ArticleNPJ vaccines2025

ALFQ adjuvanted HIV-1 envelope protein vaccination elicits durable functional antibody and cellular responses in nonhuman primates.

Shikha Shrivastava, Joshua M Carmen, Jiae Kim, Kristina K Peachman, Shraddha Basu, Ryan Alving, Danielle Nettere, Gautam Kundu, Lauren Yum, Mohammad Arif Rahman and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Shikha ShrivastavaUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Joshua M CarmenUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jiae KimUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kristina K PeachmanUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Shraddha BasuUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ryan AlvingUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Danielle NettereDuke University Medical Center, Duke Human Vaccine Institute and Department of Surgery, Durham, NC, USA.
Gautam KunduUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lauren YumUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Mohammad Arif RahmanAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Shalini JhaDuke University Medical Center, Duke Human Vaccine Institute and Department of Surgery, Durham, NC, USA.
Hung V TrinhUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lorean RosadoUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Phuong NguyenUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Elaine MorrisonUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Isabella SwaffordUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Kawthar MachmachUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Jessica S BoltonAgile Vaccines and Therapeutics, Navy Medical Research Center, Silver Spring, MD, USA.
Adam YatesHenry Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, MD, USA.
Elina MisickaHenry Jackson Foundation for the Advancement of Military Medicine Inc, Bethesda, MD, USA.
Zoltan BeckUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Simona MutascioUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Ousman JobeUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Michelle Zemil McCreaUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Lindsay WieczorekUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Elke S Bergmann-LeitnerBiologics Research and Development Branch, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Victoria PolonisUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Dominic Paquin-ProulxUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Justin PollaraDuke University Medical Center, Duke Human Vaccine Institute and Department of Surgery, Durham, NC, USA.
Gary R MatyasUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Carl R AlvingUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Rasmi ThomasUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Genoveffa FranchiniAnimal Models and Retroviral Vaccines Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Guido FerrariDuke University Medical Center, Duke Human Vaccine Institute and Department of Surgery, Durham, NC, USA.
Barton F HaynesDuke University School of Medicine, Duke Human Vaccine Institute, Departments of Medicine and Integrative Immunobiology, Durham, NC, USA.
Julie A AkeUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Mangala RaoUS Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA. mrao@hivresearch.org.

Funding

Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MOODY, MICHAEL ANTHONY · 2012 to 2018
$204.7M
Nonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodiesUM1AI144371 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2019 to 2025
$190.4M
DoD W81XWH-18-2-0040NIAID NIH HHS UM1 AI100645NIAID NIH HHS UM1 AI144371
6 · The paper itself

Abstract

Adjuvants play an important role in modulating antigen-specific immune responses. We conducted a comparative adjuvant immunogenicity study in Rhesus macaques using HIV-1 subtype B gp120 envelope protein, B.63521, formulated with aluminum hydroxide gel (AH), or a family of liposomal adjuvants known as Army Liposome Formulation (ALF). ALF comprises saturated phospholipids, cholesterol, and monophosphoryl lipid A. Inclusion of QS-21 or adsorption of the antigen to AH, followed by the addition of ALF, generates ALFQ and ALFA, while inclusion of both immunostimulants generates ALFQA. Priming with canarypox vector ALVAC, followed by boosting with ALVAC and gp120 formulated with each of the four adjuvants, resulted in ALFQ and ALFQA outperforming AH and ALFA vaccine formulations with a high frequency of antigen-specific plasma cells in the bone marrow, robust antibodies, and Env-specific polyfunctional CD8

Identifiers

PMID41419739
PMCPMC12764542

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.