ArticleBMC pregnancy and childbirth2025
An unusual case of Kippel-Trenaunay syndrome complicated with intrahepatic cholestasis of pregnancy and disseminated intravascular coagulation.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKlippel-Trenaunay syndrome (KTS) is a rare congenital vascular disorder characterized by capillary malformation, varicose veins, and limb hypertrophy. Women with KTS face increased risks of thromboembolism and hemorrhage during pregnancy, delivery, and the postpartum period. Intrahepatic cholestasis of pregnancy (ICP), the most common pregnancy-related liver disorder, is associated with adverse perinatal outcomes. However, coexistence of KTS and ICP has not been previously reported. CASE PRESENTATION: We describe the case of a 29-year-old pregnant woman with known KTS who developed ICP in the third trimester. She was managed with ursodeoxycholic acid and prophylactic anticoagulation. Despite therapy, her serum bile acids remained elevated, and fetal monitoring revealed decelerations, prompting cesarean delivery at 35 weeks of gestation. The newborn was preterm but otherwise healthy. Postpartum, the patient experienced progressive coagulopathy with markedly elevated D-dimer levels, superficial vein thrombosis, and clinical signs of disseminated intravascular coagulation (DIC). With adjustment of anticoagulation and administration of fresh frozen plasma and fibrinogen, her coagulation profile gradually normalized. She was discharged on rivaroxaban and remained stable during follow-up.
conclusionThis case highlights the complexity of managing pregnancy in women with KTS complicated by ICP. The coexistence of two high-risk conditions poses challenges in balancing thrombosis and bleeding risks, as well as safeguarding fetal outcomes. Multidisciplinary care, close monitoring, and individualized anticoagulation strategies are essential to optimize maternal and neonatal prognosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.