Evidence map›Paper›PMID 41419909›Full record

ArticleJournal of nanobiotechnology2025

Multifunctional microneedle patch loaded with microfluidic-synthesized hybrid gas-nanozyme for myocardial infarction treatment.

Ying Wang, Xiaoya Duan, Chen Men, Xi Guo, Zixu Cui, Linfei Zhang, Wei Zhuang, Hao Ren, Jiang-Kai Qiu, Kai Guo and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying Wang *College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Xiaoya Duan *School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Chen Men *Department of Gerontology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Xi GuoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Zixu CuiSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Linfei ZhangDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Wei ZhuangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China.
Hao RenSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Jiang-Kai QiuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. qiujiangkai@njtech.edu.cn.
Kai GuoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. Guok@njtech.edu.cn.
Xiangxiang ZhengDepartment of Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. zxxford123@163.com.

Funding

Jiangsu Province Capability Improvement Project through Science Technology and Education ZDXK202230National Natural Science Foundation of China 21522604National Natural Science Foundation of China 21702103National Natural Science Foundation of China 32371444
6 · The paper itself

Abstract

Myocardial infarction (MI) remains a critical global health challenge. Excessive reactive oxygen species (ROS) and intense inflammation are two primary drivers of myocardial injury, leading to cardiac dysfunction and heart failure. Herein, a multifunctional microneedle (MN) patch based on gelatin methacryloyl (GelMA) is developed to deliver a hybrid gas-nanozyme with antioxidant and anti-inflammatory activities for MI treatment. The hybrid gas-nanozyme (ZnSBS), comprising zinc sulfide (ZnS) and superoxide dismutase (SOD), is fabricated via microfluidic synthesis. It exhibits pH-responsive hydrogen sulfide (H

Indexed as

Myocardial InfarctionAnimalsAnti-Inflammatory AgentsAntioxidantsHydrogen SulfideMaleMiceMicrofluidicsNeedlesOxidative StressRatsRats, Sprague-DawleyRAW 264.7 CellsReactive Oxygen SpeciesSuperoxide DismutaseZinc CompoundsAnti-Inflammatory AgentsAntioxidantsHydrogen SulfideReactive Oxygen SpeciesSuperoxide DismutaseZinc CompoundsAnti-inflammatoryAnti-oxidantHydrogen sulfideMicrofluidic synthesisMicroneedleMyocardial infarction

Identifiers

PMID41419909
PMCPMC12831418

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.