ArticleBMC chemistry2025
A novel ultrasensitive electrochemical genosensor based on PtNPs/EEGO-AGs/AuNPs nanoassembly for rapid detection of HCMV miRNA.
Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
MicroRNAs (miRNAs) are stable and accessible biomarkers for disease diagnosis. Elevated levels of human cytomegalovirus (HCMV)-encoded miRNA-UL22A-5p (miR-UL22A-5p) are associated with virologic recurrence in transplant patients with HCMV infection and can serve as a prognostic marker. Here, we introduce the first electrochemical genosensing platform for the sensitive and accurate detection of miR-UL22A-5p in serum samples. This platform employs a ratiometric strategy to improve probe specificity within complex serum matrices. A new nanocomposite consisting of platinum nanoparticles, effectively oxidised graphene oxide aerogels, and gold nanoparticles (PtNPs/EEGO-AGs/AuNPs) was electrodeposited onto a glassy carbon electrode (GCE). This design boosts sensor performance: PtNPs provide high electrocatalytic activity for signal amplification, EEGO-AGs offer antifouling properties to reduce interference from biological matrices while serving as a substrate for further modification, and AuNPs facilitate stable thiol-mediated attachment of single-stranded DNA probes. Under optimal conditions, the nanobiosensor demonstrated a linear detection range from 10
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