Evidence map›Paper›PMID 41420089›Full record

ArticleScientific reports2025

Sex specific associations of urinary metals with TyG index in the Chinese elderly ​.

Jinhao Jia, Bing Wu, Zhongyuan Zhang, Siyu Duan, Yuqing Dai, Meiyan Li, Zhuoheng Shen, Pei He, Rui Wang, Limeng Xiong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jinhao Jia *School of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Bing Wu *School of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Zhongyuan Zhang *School of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Siyu DuanSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Yuqing DaiSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Meiyan LiSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Zhuoheng ShenSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Pei HeSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Rui WangSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Limeng XiongSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
ZeYang BaiSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Jiaming FuSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Yuhan ZhangSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Xiaoyu LiSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Yi ZhaoSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Rui ZhangSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China.
Huifang YangSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China. joyceyhf@163.com.
Yue SunSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China. sunyue@nxmu.edu.cn.
Jian SunSchool of Public Health, General Hospital of Ningxia Medical University, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People's Republic of China. 20180016@nxmu.edu.cn.

Funding

Key Research and Development Program of Ningxia 2024FRD0510The 2022 "Light of the West" Talent Training Plan Project of the Chinese Academy of Sciences XAB2022YW18The Key Research and Development Program Project of Ningxia Hui Autonomous Region 2023BEG02028The National Natural Science Foundation of China U22A20360
6 · The paper itself

Abstract

This study examined associations between urinary metal exposure and the triglyceride glucose (TyG) index, a recognized metabolic risk marker for cardiovascular events. Analyzing urine samples from 3764 participants via inductively coupled plasma mass spectrometry (ICP‒MS), researchers addressed limitations of single-metal models and sex-specific knowledge gaps. Using least absolute shrinkage and selection operator (LASSO) regression and multi-metal generalized linear models (GLMs), findings revealed positive correlations between urinary arsenic (As), zinc (Zn), molybdenum (Mo), tellurium (Te) and the TyG index, while iron (Fe), selenium (Se) and cadmium (Cd) showed negative correlations. Weighted quantile sum (WQS) regression highlighted sex differences: Te contributed most strongly to positive associations in males, whereas Mo dominated in females; Fe contributed most to negative associations in both sexes. Bayesian kernel machine regression (BKMR) models indicated increasing cumulative effects of metal mixtures across higher exposure quartiles, suggesting a potential interaction between Zn and Cd—though generalized additive models (GAM) analysis found this statistically insignificant. The study concludes that specific urinary metal levels correlate with the TyG index, demonstrating significant sex-based variation in these associations.

Indexed as

MetalsTriglyceridesAgedBiomarkersChinaEast Asian PeopleFemaleHumansMaleSex FactorsZincBiomarkersMetalsTriglyceridesZincBKMRCross-sectional studyMultimetalOlder adultsSex specificTriglyceride glucose index

Identifiers

PMID41420089
PMCPMC12827937

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.