ArticleTrials2025
Endogenous and/or exogenous origin of phenolic metabolites in humans (the ENDOPHENOL project): study protocol for a randomized, controlled, crossover trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites Using (un)Targeted Metabolomics
Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites in People With an Ileostomy Using an Oral (Poly)Phenol Challenge Test
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
background(Poly)phenols are molecules with various structural complexities that are mostly present in fruits, vegetables, and some cereals, and are widely consumed daily. Following ingestion, the phenolic compounds that are not absorbed in the upper gastrointestinal tract-the majority-are metabolized in the colon to form low-molecular-weight phenolic catabolites (LMWP), which potentially make a substantial contribution to the biological activity of (poly)phenol-containing foods. However, the production of LMWP can also occur through the metabolism of the aromatic amino acids phenylalanine and tyrosine as well as via catecholamine pathways.
methodsA randomized, controlled, crossover trial in which healthy adults (n = 30) follow a very-low-(poly)phenol diet and restrict physical activity for 5 days is proposed. On the morning of the third day, subjects will consume either coffee (known source of (poly)phenols) or hot water (control). DISCUSSION: The main objective is the characterization of LMWP in biological samples through metabolomic techniques, attempting to distinguish the possible origin of these metabolites based on the different production of LMWP in the context of a controlled diet with or without a known source of (poly)phenols (primary outcome). Factors leading to interindividual variability and playing a role in phenolic metabolism, such as gut microbiota composition and genetic polymorphisms (secondary outcomes), will also be considered. Emerging evidence suggests that endogenous metabolism also contributes to circulating LMWP, which could lead to an overestimation of their attribution to dietary (poly)phenols. By implementing a long washout and using coffee as the test source, this study aims to capture background phenolic production and better disentangle dietary from endogenous contributions. These insights will support a more accurate understanding of the role of LMWP in nutrition and health.
trial registrationThis study was approved by the Territorial Ethics Committee (CET) of Area Vasta Emilia Nord (AVEN) (340/2023/SPER/UNIPR). CLINICAL TRIALS REGISTRATION: NCT06028659. Registered on 23 August 2023.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.