ArticlePhysiological reports2025
Intercerebral autoregulation index consistency in the derivation of CPPopt, MAPopt, and BISopt in humans: A scoping review.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Intercerebral autoregulation index consistency in the derivation of CPPopt, MAPopt, and BISopt in humans: A scoping review.Physiological reports · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
The optimization of cerebral perfusion and sedation using autoregulation-derived physiologic targets such as optimal cerebral perfusion pressure (CPPopt), optimal mean arterial pressure (MAPopt), and optimal bispectral index (BISopt) has emerged as a promising strategy in neurocritical and perioperative care. However, the reliability and comparability of these optimal (Opt) parameters across different autoregulatory indices remain uncertain. This paper systematically reviews and synthesizes literature comparing CPPopt, MAPopt, and BISopt derived from invasive and noninvasive indices. Following PRISMA-ScR guidelines, studies directly comparing CPPopt, MAPopt, or BISopt from at least two indices were included. Ten studies compared CPPopt, mostly in traumatic brain injury, with mean values between 70 and 76 mmHg. Nine studies compared MAPopt, reporting strong correlations between transcranial doppler-, near-infrared spectroscopy-, and intracranial pressure-derived indices across populations, though limits of agreement were wide. One study compared BISopt across indices, showing internal consistency, while two cross-Opt studies found little correlation between BISopt and CPPopt or MAPopt. CPPopt and MAPopt appear physiologically robust across indices, supporting translational potential in both invasive and noninvasive settings. BISopt may represent a distinct optimization domain related to sedation rather than perfusion. Methodological heterogeneity and limited outcome validation remain barriers. Future work should emphasize standardization, multimodal integration, and outcome-driven trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.