ArticlePhysiological reports2025
An algorithm for generating biophysically realistic three-dimensional arteriolar networks applied to rat skeletal muscle.
Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- An algorithm for generating biophysically realistic three-dimensional arteriolar networks applied to rat skeletal muscle.Physiological reports · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
The microcirculation comprises small vessel networks that regulate blood perfusion within tissues. The relationship between tissue shape or size and its microvascular properties is not yet clear. This study develops an algorithm for computationally simulating branching arteriolar networks within ellipsoidal tissue volumes, including user-adjustable parameters (e.g., tissue width-length-height dimensions and microvessel density) for application within different rodent skeletal muscles. The algorithm is developed using principles from constrained constructive optimization, an iterative network generation framework based on proposed mechanisms of vascular growth. Networks generated within muscles of varying shapes and sizes were analyzed over a range of geometric (e.g., mean diameter, length, and number of bifurcations per Strahler's and centrifugal order, fractal dimension) and hemodynamic (e.g., Murray's law exponent, hematocrit) properties. Statistical similarity was observed across different skeletal muscle tissues, with differences due to tissue shape being observed only above a vessel diameter threshold of ~25 μm (varying at large or small tissue volumes at the scale m
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.