Evidence map›Paper›PMID 41420841›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Nucleoside-Based Hydrogel Platform Synergizes with Photothermal Effects for Enhanced Biofilm Eradication Against Periodontitis.

Yinghui Wen, Yunfei Li, Tiannan Liu, Chongkui Sun, Hang Zhao, Yao Yuan, Shiping Yang, Tingxing Zhao, Jiang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Chiral FeBioactive materials · 2026
    Article
  3. Melittin-Loaded FeInternational journal of nanomedicine · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yinghui WenState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.
Yunfei LiSchool of Materials and Chemistry, Southwest University of Science and Technology, Mianyang, Sichuan, P. R. China.
Tiannan LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.
Chongkui SunDepartment of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology, Chengdu, Sichuan, P. R. China.
Hang ZhaoState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.
Yao YuanState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.
Shiping YangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan, P. R. China.
Tingxing ZhaoSchool of Materials and Chemistry, Southwest University of Science and Technology, Mianyang, Sichuan, P. R. China.
Jiang LiuState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Research Unit of Oral Carcinogenesis and Management & Chinese Academy of Medical Sciences, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, P. R. China.ORCID https://orcid.org/0000-0002-5336-7354

Funding

Doctoral Research Foundation of Southwest University of Science and Technology 22zx7129National Key R&D Program of China 2022YFB3203800National Natural Science Foundations of China 52503203National Natural Science Foundations of China 82271035National Natural Science Foundations of China 82571099National Natural Science Foundations of China 82571160Sichuan Science and Technology Bureau 2021YJ0564
6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease primarily driven by pathogenic biofilms, and affects more than 90% of the global population. The increasing prevalence of bacterial resistance, coupled with the protective nature of resilient biofilms, makes it challenging to achieve satisfactory therapeutic outcomes. In this study, an organic small molecule-based photothermal reagent (FNP) with excellent photothermal property is designed by rational tailor of donor-acceptor combinations, and a supramolecular nucleoside hydrogel (ZBAg) is developed via silver ion-stabilized base pairing and dynamic boronate ester bonds. The ZBAg hydrogel exhibits a unique coordination mechanism distinct from the traditional intermolecular i-motif coordination mode. The ZBAg@FNP hydrogel is prepared by encapsulating FNP within ZBAg hydrogel, which demonstrates excellent biocompatibility and achieves controlled Ag

Indexed as

BiofilmsHydrogelsNucleosidesPeriodontitisPhotothermal TherapyAnimalsHumansMalePorphyromonas gingivalisRatsRats, Sprague-DawleySilverStreptococcus mutansHydrogelsNucleosidesSilverantibacterialantibiofilmnucleoside‐based hydrogelperiodontitisphotothermal therapy

Identifiers

PMID41420841
PMCPMC12955991

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.