Evidence map›Paper›PMID 41420858›Full record

ReviewCell reports2026

Distinct precursor landscape of subcutaneous and visceral fat in development and aging.

Frances Lin, Hei Sook Sul

Abstract readReview
In one paragraph

Review in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Frances LinDepartment of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Hei Sook SulDepartment of Nutritional Sciences & Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: hsul@berkeley.edu.

Funding

MICT1 function in thermogenesisR01DK134757 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Hei Sook Sul · 2023 to 2026
$2.1M
Enhancer for UCP1 transcription and thermogenesisR01DK140318 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI Hei Sook Sul · 2024 to 2026
$1.7M
Aging-Dependent Changes in Adipose TissueF31DK132867 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI LIN, FRANCES · 2022 to 2025
$134k
NIDDK NIH HHS F31 DK132867NIDDK NIH HHS R01 DK134757NIDDK NIH HHS R01 DK140318
6 · The paper itself

Abstract

White adipose tissue (WAT) is the primary energy storage organ and can be categorized mainly into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Although all WAT accumulates triglycerides to store excess energy, VAT is associated with pathological conditions, whereas SAT is considered beneficial for metabolic health. In fact, SAT and VAT are from distinct developmental origins. Moreover, within these depots, there is heterogeneity in developmental origin and in adipose precursor population. In various conditions, such as obesity and aging, adipose tissue undergoes distinct changes. In aging, pathogenic VAT tends to increase, whereas protective peripheral SAT is known to be reduced significantly, but the mechanism driving this depot-specific reduction in SAT is not well understood. Here, we review recent research on depot-specific adipose precursor heterogeneity in SAT and VAT and new and distinct adipose precursor populations arising in SAT and VAT during aging to bring differential changes in adipose mass.

Indexed as

AgingIntra-Abdominal FatSubcutaneous FatAnimalsHumansObesityadipocytesadipose precursorsagingCP: MetabolismSATsubcutaneous adipose tissueVATvisceral adipose tissue

Identifiers

PMID41420858
PMCPMC12883077

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.