ArticleAnnals of medicine2025
Single-cell transcriptomics reveals an abnormal immune microenvironment in plasma cell mastitis.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prolactin-Linked Plasma Cell-Macrophage Immune Phenotype in Synchronous Bilateral Plasma Cell Mastitis: A Two-Center Prediction Study with Tissue Correspondence.International journal of women's health · 2026Article
- Immune imbalance and autoimmune mechanisms in plasma cell mastitis: current perspectives.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPlasma cell mastitis (PCM) is a non-bacterial inflammatory breast disorder affecting young and middle-aged nonpregnant and nonlactating women. However, a comprehensive and systematic analysis of PCM has not been conducted. METHODS AND
resultsComprehensive cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) analysis was performed on 10,185 cells derived from PCM tissue to generate a highly detailed transcriptomic atlas. Thirteen distinct clusters were identified, and eight cell types were successfully annotated, including endothelial cells, common myeloid progenitor cells and neutrophils. Additionally, the overall alterations in immune cell composition in PCM patients were evaluated. Furthermore, differentially expressed genes between normal and PCM samples were assessed, and functional enrichment analysis was conducted. Finally, cellular communication and interaction were analysed to determine cell-to-cell communications.
conclusionThis study significantly contributes to the field of PCM, presenting a systematic and valuable perspective that serves as a fundamental resource for further exploration of the cellular and molecular mechanisms, pathogenesis of associated diseases and potential interventions.
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Registered trials
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