ArticleEuropean journal of clinical nutrition2026
Relationship between the dietary inflammatory index and immune function during pregnancy - A secondary analysis of the MicrobeMom2 Study.
Article in European journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesThe maternal immune system requires careful regulation during pregnancy to prevent complications such as preeclampsia and prematurity. Inflammatory immune states may be linked to maternal diet throughout pregnancy. Although gestational changes in cytokines are well-documented, the association with the inflammatory potential of diet has not been robustly explored. This study investigates the associations between maternal dietary inflammatory potential, measured by energy adjusted dietary inflammatory index (E-DII) in late pregnancy (28-32 weeks' gestation). SUBJECTS/
methodsE-DII was calculated using 6-month food frequency questionnaires completed by pregnant mothers at 28-32 weeks' gestation. Serum cytokine levels from maternal blood samples were measured using Cobas® and ProteinSimple ELLA immunoassay, while PBMC derived cytokine levels were assessed using BioLegend LEGENDplex™.
resultsThe study included 68 pregnant women, with a mean age (SD) at recruitment of 33.01(4.6) years and median BMI (IQR) of 24.95 (21.87, 27.57) kg/m
conclusionsDiet may hold potential to promote optimal maternal inflammatory states. These data may inform nutritional guidelines to reduce pregnancy related complications, especially for mothers with higher background metabolic risk, such as those living with obesity.
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