Evidence map›Paper›PMID 41422437›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.

Shubo Yuan, Jiafu Li, Min Shao, Haili Bao, Ajun Geng, Jialin Yang, Yu Tao, Xinyi Chen, Tianxiong Xiao, Chunye Liu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. CD168 Identifies Proliferating Pancreatic Islet Cells in Murine and Human.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Shubo YuanNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Jiafu LiNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Min ShaoNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Haili BaoDepartment of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, China.
Ajun GengKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Jialin YangNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Yu TaoKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Xinyi ChenKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Tianxiong XiaoKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Chunye LiuNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Zhiyao XieNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Wenqian SongKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Qing Cissy YuNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Hongxing FuDepartment of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Xu HanDepartment of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Taochen HeDepartment of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wenquan WangDepartment of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jianfeng ChenKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, 310024, China.
Sheng YanDepartment of Hepatobiliary and Pancreatic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Shaohua SongDepartment of General Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200025, China.
Liang LiuDepartment of Pancreatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yi Arial ZengNew Cornerstone Science Laboratory, Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.ORCID https://orcid.org/0000-0003-1898-8099

Funding

CAS-Croucher Funding Scheme for Joint Laboratories CAS 24801CAS Project for Young Scientists in Basic Research YSBR-014National Key Research and Development Program of China 2020YFA0509002National Key Research and Development Program of China 2020YFA0509003National Natural Science Foundation of China 32030024National Natural Science Foundation of China 32588301National Natural Science Foundation of China 82270684National Natural Science Foundation of China 82272929National Natural Science Foundation of China 82273382National Natural Science Foundation of China 82473459New Cornerstone Science Foundation NCI202254Science and Technology Commission of Shanghai Municipality 22JC1402202Science and Technology Commission of Shanghai Municipality 23J21901400Shanghai Municipal Science and Technology Major Project
6 · The paper itself

Abstract

Restoring functional β-cell mass through proliferation is a central goal of diabetes therapy, but progress has been hampered by the inability to isolate live, proliferating β-cells for study. Here, CD168 is identified as a conserved surface marker that specifically enriches for proliferating cells in mouse and human pancreatic islets. Single-cell RNA sequencing reveals a distinct cluster of islet cells with high proliferative activity, low insulin expression, and specific CD168 expression. Flow cytometry and immunostaining confirm CD168

Indexed as

Cell ProliferationInsulin-Secreting CellsIslets of LangerhansAnimalsHumansMiceCD168cell surface markerpancreatic isletsβ‐cell maturationβ‐cell proliferation

Identifiers

PMID41422437
PMCPMC12915181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.