Evidence map›Paper›PMID 41422479›Full record

ArticleMolecular oncology2026

Therapeutic strategies for MMAE-resistant bladder cancer through DPP4 inhibition.

Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada and 1 more

Abstract read
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In one paragraph

Article in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gang LiDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Shuichi TataranoDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Hirofumi YoshinoDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.ORCID 0000-0002-5470-7445
Saeki SaitoDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Mitsuhiko TominagaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Junya ArimaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Ikumi FukudaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Takashi SakaguchiDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Ryosuke MatsushitaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Yasutoshi YamadaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.
Hideki EnokidaDepartment of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.ORCID 0000-0002-3050-9700

Funding

Japan Society for the Promotion of Science 21K09430Japan Society for the Promotion of Science 22K09452Japan Society for the Promotion of Science 22K09507Japan Society for the Promotion of Science 22K16820
6 · The paper itself

Abstract

Monomethyl auristatin E (MMAE) is used as the cytotoxic payload for enfortumab vedotin (EV) in the treatment of locally advanced and metastatic bladder cancer (BC). However, the development of resistance to MMAE in BC is a therapeutic problem. To explore the mechanism of resistance to MMAE in BC, we established MMAE-resistant BC cells (MR-BCs). RNA sequencing analysis showed that the expression of dipeptidyl peptidase 4 (DPP4, also called CD26) increased significantly in MR-BCs compared with parental BC cells. Knock down of DPP4 expression using small interfering RNA inhibited the viability of MR-BCs. In addition, the DPP4 inhibitor sitagliptin suppressed the proliferation, migration, and invasion of BC cells, and cotreatment with MMAE effectively induced cell apoptosis, arrested cells in the G

Indexed as

Dipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsDrug Resistance, NeoplasmOligopeptidesUrinary Bladder NeoplasmsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationFemaleHumansMiceMice, Inbred BALB CMice, NudeProto-Oncogene Proteins c-aktDipeptidyl Peptidase 4Dipeptidyl-Peptidase IV InhibitorsDPP4 protein, humanOligopeptidesProto-Oncogene Proteins c-aktReactive Oxygen SpeciesSitagliptin PhosphateAKTbladder cancerdipeptidyl peptidase 4monomethyl auristatin Esitagliptin

Identifiers

PMID41422479
PMCPMC13155154

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.