ArticleAddiction biology2025
Behavioural, Neural and Molecular Effects Underlying Caffeine's Addictive Properties.
Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Behavioural, Neural and Molecular Effects Underlying Caffeine's Addictive Properties.Addiction biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caffeine is one of the most widely consumed psychoactive substances globally. It acts as a non-selective adenosine receptor antagonist. Despite its extensive use, the effects of caffeine on the central nervous system remain poorly understood. This study aims to investigate the behavioural changes and underlying neural mechanisms associated with caffeine addiction. The results of conditioned place preference (CPP) revealed that caffeine induces a strong preference shift, demonstrating its rewarding properties. 3D Behavioural Profiling and Motion Analysis further demonstrated significant differences in locomotion, rearing and sniffing behaviours between caffeine-treated and saline-treated groups. C-fos and fibre photometry experiments revealed that caffeine activates the medial prefrontal cortex (mPFC) region. Transcriptomic profiling revealed a significant enrichment of pathways associated with transcriptional regulation and calcium signalling in the medial prefrontal cortex (mPFC) of caffeine-treated mice. Together, these findings provide a multidimensional perspective on caffeine's addictive properties, as well as its modulation of mPFC activity and molecular pathways. This contributes to a deeper understanding of caffeine's effects on the central nervous system.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.