Evidence map›Paper›PMID 41423640›Full record

ArticleScientific reports2025

Interplay Between Enteroendocrine Hormone (Leptin) and Adipokines (Ghrelin and Adiponectin) with Gastric Expression of FTO and MC4R Genes.

Mohamed Hany, Mona K ElDeeb, Ehab Elmongui, Anwar Ashraf Abouelnasr, Noha A El-Banna, Sahar M Omer, Sara A Shaker, Rasha A ElTahan

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Mohamed HanyBariatric and Metabolic Surgery, Madina Women's Hospital, Alexandria, Egypt. mohamed.ashour@alexu.edu.eg.ORCID 0000-0001-6650-8112
Mona K ElDeebClinical Laboratory Sciences, Jouf University, Sakaka, Saudi Arabia.
Ehab ElmonguiIndependent Biostatistical Consultant, Alexandria, Egypt.
Anwar Ashraf AbouelnasrDepartment of Surgery, Medical Research Institute, Alexandria University, Alexandria, Egypt.ORCID 0009-0007-5718-994X
Noha A El-BannaChemical Pathology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Sahar M OmerChemical Pathology Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Sara A ShakerBiochemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Rasha A ElTahanBiochemistry Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a complex, multifactorial disease influenced by genetic, hormonal, and metabolic factors. The fat mass and obesity-associated (FTO) and melanocortin 4 receptor (MC4R) genes have been implicated in body weight regulation through gut–brain signaling and their interactions with adipokines and enteroendocrine hormones. This study investigated the association between gastric expression of FTO and MC4R genes and circulating levels of leptin, adiponectin, and ghrelin in individuals with and without obesity. We conducted a case–control study including 50 patients with obesity undergoing sleeve gastrectomy and 50 controls undergoing diagnostic endoscopy. Gastric tissue gene expression was assessed by qRT-PCR, and serum hormone levels were quantified using ELISA. Inverse propensity score weighting was used to adjust for age and sex. FTO expression was significantly upregulated in patients with obesity (fold-change: 5.8 vs. 1.0, p < 0.001), showing a parallel elevation with adiponectin and BMI at the group level. In contrast, MC4R expression was significantly downregulated (fold-change: 0.1 vs. 1.0, p < 0.001), and positively associated with HOMA-IR and showed a borderline positive trend with fasting blood glucose (p = 0.074). Adiponectin levels were paradoxically elevated in the obesity group and correlated with both BMI and HDL. Leptin and ghrelin levels showed no significant group differences. These findings suggest that altered gastric expression of FTO and MC4R may contribute to obesity-related metabolic disturbances through peripheral adipokine pathways. Further investigation into tissue-specific gene–hormone interactions may inform novel therapeutic strategies for obesity.

Indexed as

AdiponectinAlpha-Ketoglutarate-Dependent Dioxygenase FTOGastric MucosaGhrelinLeptinObesityReceptor, Melanocortin, Type 4AdipokinesAdultCase-Control StudiesFemaleGene Expression RegulationHumansMaleMiddle AgedAdipokinesAdiponectinADIPOQ protein, humanAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanGhrelinLeptinMC4R protein, humanReceptor, Melanocortin, Type 4AdipokinesFTO geneGastric gene expressionLeptinMC4R geneObesity

Identifiers

PMID41423640
PMCPMC12722424

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.