Evidence map›Paper›PMID 41423888›Full record

ArticleEndocrinology, diabetes & metabolism2026

Association Between Dietary Fatty Acid Intake With Cardiovascular Disease Risk and Serum Lipid Levels.

Naeemeh Hassanpour Ardekanizadeh, Khadijeh Abbasi Mobarakeh, Sheyda Nami, Maryam Shojaei, Seyed Fazel Nasimi, Saba Moradi, Faezeh Tejareh, Yeganeh Shekari, Parsa Bahmani, Maryam Gholamalizadeh and 3 more

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In one paragraph

Article in Endocrinology, diabetes & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Naeemeh Hassanpour ArdekanizadehDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Khadijeh Abbasi MobarakehFood Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Sheyda NamiIran University of Medical Sciences, Tehran, Iran.
Maryam ShojaeiCentral Research Laboratory, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Fazel NasimiMaster of Science in Nutrition and Exercise Physiology, Zand Institute of Higher Education, Shiraz, Iran.
Saba MoradiDepartman of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
Faezeh TejarehDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran Medical Branch, Tehran, Iran.
Yeganeh ShekariDepartment of Nutrition, Faculty of Medical Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Parsa BahmaniDepartment of Community Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam GholamalizadehUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Marjan AjamiDepartment of Food and Nutrition Policy and Planning, School of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Akram KooshkiNon-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Saeid DoaeiUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.ORCID https://orcid.org/0000-0002-2532-7478

Funding

Sabzevar University of Medical Sciences 99218
6 · The paper itself

Abstract

backgroundDespite early interest in the effects of dietary fats on cardiovascular diseases (CVDs), substantial controversy remains regarding the evidence linking different types of fatty acids to CVDs. This study aimed to examine the association between dietary fat intake, CVD risk, and serum lipid biomarkers.

methodsThis cross-sectional study included data from 4200 adult participants (1218 patients with CVDs and 2982 healthy participants) from the Persian Cohort Study. Data on heart disease (hypertension, myocardial infarction, and ischemic heart disease) were collected. Dietary intake was assessed using a validated food frequency questionnaire (FFQ), and the intake of different fatty acids was evaluated using Nutritionist-IV software. Serum lipid profiles were analysed using enzymatic and chromatographic methods.

resultsHigher monounsaturated fatty acids (MUFA) intake showed an inverse association with CVDs (OR = 0.931, 95% CI: 0.867-0.998, p = 0.045). Adjustments for age, gender, smoking, alcohol consumption, physical activity, BMI, and caloric intake did not alter this association. No significant associations were observed for other dietary fats.

conclusionThe findings suggest an inverse association between MUFA intake and CVD risk. Further longitudinal studies are warranted to confirm these results.

Indexed as

Cardiovascular DiseasesDietary FatsFatty AcidsLipidsAdultAgedBiomarkersCross-Sectional StudiesFatty Acids, MonounsaturatedFemaleHumansIranMaleMiddle AgedRisk FactorsBiomarkersDietary FatsFatty AcidsFatty Acids, MonounsaturatedLipidscardiovascular diseasedietary fatslipid profilemonounsaturated fatty acids

Identifiers

PMID41423888
PMCPMC12719392

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.