ReviewInternational journal of nanomedicine2025
Bond-Centric Modifications of Hyaluronic Acid: Synthesis, Processing, and Biomedical Applications.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- Research advances in intelligent microenvironment-responsive hydrogels for myocardial infarction therapy.APL bioengineering · 2026Review
- Crosslinking-Dependent Design of Hyaluronic Acid Matrices for Enhanced Bioadhesion and Cellular Response.Pharmaceutics · 2026Article
- Hyaluronic Acid-Based Biomaterials in Tissue Engineering: From Molecular Properties to Re-Generative Applications.Journal of functional biomaterials · 2026Review
- Hydrogel-Based Platforms for Wound Care: Integrated Strategies for Antimicrobial Delivery and Biofilm Management.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyaluronic acid (HA), a natural polysaccharide present in human connective tissues, is widely used in biomedicine because of its excellent biocompatibility and biodegradability. However, products based on natural HA have several drawbacks, leading to widespread studies on the modification and processing of HA to improve its clinical use. This review discusses common methods of modifying HA, including physical and chemical modification as well as crosslinking. It focuses in detail on various chemical modification strategies from the perspective of the resultant chemical bonds, systematically organizes HA chemistry according to bond types, and refines the design rules for linking chemistry in relation to degradability, mechanical properties, responsiveness, and safety. It then summarizes the latest applications of HA-based products in the fields of ophthalmology, bone and joint treatment, aesthetic medicine, wound healing, and drug delivery. Finally, it explores challenges for the clinical application of HA and provides an outlook on future research directions. By summarizing the applications of HA across distinct biomedical domains, we hope to provide new ideas and directions for its further development and use.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.