ArticleFrontiers in oral health2025
ORASPORT study protocol: a prospective observational study on the impact of endurance physical activity on oral microbiology and immunology.
Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05765422 (Sport and Health a Pilot Study), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sport and Health a Pilot Study: Impact of Endurance Physical Activity on the Microbiological Homeostasis of the Oral Cavity of Young Adults
Who cites it
2 citing papers in PubMed.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral cavity offers a non-invasive window into systemic health. Elite athletes often present with poor oral health, potentially linked to high physiological stress, psychological strain, and specific dietary habits. This study explores the relationship between physical activity and oral health, with a particular focus on identifying key changes in the oral microbiota and salivary immune profiles. The main objective is to compare the composition of oral microbiota and the levels of salivary cytokines among young healthy individuals with varying levels of endurance physical activity. The ORASPORT study is a prospective cross-sectional non-interventional study involving 200 participants recruited in a single center. The participants are healthy young individuals aged 18-30, with or without regular endurance physical activity. They will be divided into three groups according to their physical activity level, following international guidelines set by the World Health Organization (WHO). For each consenting participant, a standardized oral health assessment will be conducted by a dentist to establish a comprehensive oral health profile. Participants will also complete a detailed questionnaire to document individual data on physical activity, dietary habits, and overall health status. Additionally, oral biological samples, including saliva and gingival smears, will be collected for microbiological analysis and cytokine detection. Microbiological analysis of all oral samples will be performed using high-throughput qPCR with Biomark HD™ technology, to simultaneously detect 40 oral bacterial species, selected to represent both commensal and pathogenic oral flora, as well as the presence of 8 Human Herpesviruses (HHVs). Concurrently, the salivary concentrations of 9 inflammatory cytokines will be quantified using Meso Scale Discovery® multiplex immunoassays. Statistical analysis will include both univariate and multivariate models to identify correlations between physical activity, oral health parameters, and microbial-immune profiles. This study protocol integrates clinical, microbiological, and immunological analysis to identify non-invasive biomarkers of oral health and physical performance. This study complies with French bioethics regulations (Jardé Law) and with data protection under European GDPR requirements. It received French ethical approval from the Committee for the Protection of Persons in February 2023. Findings will be shared through publications in peer-reviewed journals and presentations at international conferences. Clinical trial number: NCT05765422.
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