Evidence mapPaperPMID 41424686Full record

ArticleCurrent research in physiology2025

Sex differences in the association between albuminuria and vascular health in individuals living with chronic kidney disease.

Badal S B Pattar, Sofia B Ahmed, Jessalyn K Holodinsky, Nicole Larsen, Sakshi Kharbanda, Sarah Rabi, Victoria Riehl-Tonn, Darlene Y Sola, Sarah Blayney, Sandra M Dumanski

Abstract read
In one paragraph

Article in Current research in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Badal S B PattarCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Sofia B AhmedCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Jessalyn K HolodinskyCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Nicole LarsenCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Sakshi KharbandaCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Sarah RabiCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Victoria Riehl-TonnCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Darlene Y SolaCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Sarah BlayneyCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.
Sandra M DumanskiCumming School of Medicine, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is the leading cause of death in chronic kidney disease (CKD). Albuminuria, a marker of CKD severity, is independently associated with cardiovascular disease, however limited studies explore the impact of sex. We aimed to explore sex differences in the association between albuminuria and vascular health in individuals living with CKD. Albuminuria was quantified through urine albumin-to-creatinine ratio (uACR) and measures of vascular health included Aortic Augmentation Index (AIx), Pulse Wave Velocity (PWV) and Mean Arterial Pressure (MAP). Multivariable linear regression analyses estimated the association between uACR and each outcome, and sex was assessed as an effect modifier. Adults living with CKD were recruited from nephrology clinics in Calgary, Canada and 66 participants (39 female, 27 male) were included in this study. A higher eGFR (89[56] versus 58[50] ml/min/1.73m2) and lower uACR (32[405] versus 386[933] mg/g) were observed in females. Sex modified the relationship between uACR and AIx; with a positive association in females (

Indexed as

AlbuminuriaCardiovascular diseaseChronic kidney diseaseSex differencesVascular health

Identifiers

PMID41424686
PMCPMC12717631

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.