ArticleFrontiers in pharmacology2025
Ibogaine's potential role in supporting reward system recovery across diagnostic boundaries.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
This article proposes that ibogaine's induction of GDNF, modulation of glutamate and dopamine signaling, and reopening of plasticity represent a unified mechanism capable of restoring reward system fidelity across disorders. This includes addiction, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and eating disorders, amongst others. These conditions are labelled as distinct and separate yet share disrupted dopaminergic and glutamatergic signaling within the mesocorticolimbic circuitry as a common underlying dysfunction, resulting in maladaptive reinforcement and motivational dysregulation. Ibogaine, a little-known indole alkaloid derived from
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