Evidence map›Paper›PMID 41424840›Full record

ArticleTheranostics2026

Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models.

Preethi Korangath, Hayden Carlton, Toby Sanders, Olivia C Sehl, Suqi Ke, Abdul Rahman Mohtasebzadeh, Lyndsey Werhane, Cordula Grüttner, Chen Hu, Kathleen Gabrielson and 2 more

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Preethi KorangathDept of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Hayden CarltonDept of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Toby SandersMagnetic Insight Inc., Alameda, California, USA.
Olivia C SehlMagnetic Insight Inc., Alameda, California, USA.
Suqi KeDivision of Quantitative Sciences, Sidney Kimmel Comprehensive Cancer Centre, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Abdul Rahman MohtasebzadehMagnetic Insight Inc., Alameda, California, USA.
Lyndsey WerhaneDept of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Cordula GrüttnerMicromod Partikeltechnologie GmbH, Rostock, Germany.
Chen HuDept of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Kathleen GabrielsonDepartment of Molecular and Comparative Pathobiology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Patrick W GoodwillMagnetic Insight Inc., Alameda, California, USA.
Robert IvkovDept of Radiation Oncology and Molecular Radiation Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Translational Application of Magnetic Hyperthermia Therapy with Adjuvant Therapies for GlioblastomaR01CA247290 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HADJIPANAYIS, CONSTANTINOS GEORGE, IVKOV, ROBERT · 2020 to 2024
$3.5M
Precision magnetic hyperthermia by integrating magnetic particle imagingR01CA257557 · NCI · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W., IVKOV, ROBERT · 2021 to 2025
$3.2M
Development of a prototype clinical theranostic platform combining Magnetic Particle Imaging (MPI) and Magnetic Fluid Hyperthermia (MFH) for the treatment of brain tumorsR44CA285064 · NCI · MAGNETIC INSIGHT, INC. · PI GOODWILL, PATRICK · 2023 to 2024
$2.0M
Magnetic Particle Imaging ScannerS10OD026740 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2019 to 2019
$600k
Leveraging Nanoparticle Interactions with Host Immune Cells to Detect and Treat CancerR50CA305053 · NCI · JOHNS HOPKINS UNIVERSITY · PI Preethi C Korangath · 2025 to 2026
$289k
NCI NIH HHS P30 CA006973NCI NIH HHS R01 CA247290NCI NIH HHS R01 CA257557NCI NIH HHS R44 CA285064NCI NIH HHS R50 CA305053NIH HHS S10 OD026740
6 · The paper itself

Abstract

Early detection of metastatic disease improves cancer survival, yet existing modalities are limited in their detection capabilities. We propose that magnetic particle imaging (MPI), an emerging technology, can be used for early detection of primary tumors and metastases. MPI detects minute quantities of magnetic particles that act as "cold tracers" which accumulate in areas of high immune activity.

Indexed as

Breast NeoplasmsLung NeoplasmsMagnetite NanoparticlesNanoparticlesNeoplasm MetastasisAnimalsCell Line, TumorDisease Models, AnimalFemaleHumansMiceMagnetite Nanoparticlesiron oxide nanoparticlesmacrophagesmagnetic particle imagingmetastasis detectionstromal cellstumor microenvironment

Identifiers

PMID41424840
PMCPMC12712802

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.