Evidence map›Paper›PMID 41424850›Full record

ArticleTheranostics2026

Focused ultrasound-enhanced nose-to-brain delivery of a therapeutic antibody in a large-animal model.

Siaka Fadera, Cristian Antonio Wieczorek Villas Boas, Yimei Yue, Zhaoning Gu, Jinyun Yuan, Debolina De, Buck E Rogers, Arash Nazeri, Hong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siaka FaderaDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Cristian Antonio Wieczorek Villas BoasDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Yimei YueDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Zhaoning GuDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Jinyun YuanDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Debolina DeMallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Buck E RogersDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Arash NazeriDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.
Hong ChenDepartment of Biomedical Engineering, Washington University in St. Louis, Saint Louis, MO, 63130, USA.

Funding

Image-guided focused ultrasound-mediated intranasal brain drug delivery technique (FUSIN)R01EB027223 · NIBIB · WASHINGTON UNIVERSITY · PI Hong Chen · 2019 to 2026
$4.3M
NIBIB NIH HHS R01 EB027223
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BrainDrug Delivery SystemsAdministration, IntranasalAnimalsBlood-Brain BarrierFemaleMagnetic Resonance ImagingModels, AnimalSwineTissue Distributionanti-programmed death-ligand 1 antibodyfocused ultrasoundglymphatic transportintranasal brain drug deliverymicrobubblenose-to-brain delivery

Identifiers

PMID41424850
PMCPMC12712798

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.