ArticleACS measurement science au2025
Upscaling the Hyperpolarization Sample Volume of an Automated Hydrogenative Parahydrogen-Induced Polarizer.
Article in ACS measurement science au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Field Cycling from 10 nT to 9.4 T: A Flexible Gear Rod Design for Nuclear Spin Relaxation and Hyperpolarization Studies.ACS measurement science au · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI) suffer from inherently low sensitivity due to the weak thermal polarization of nuclear spins. Parahydrogen-induced polarization (PHIP) offers a powerful route to enhance NMR signals by several orders of magnitude, enabling real-time metabolic imaging. However, PHIP implementations are often constrained by small sample volumes, limited automation, and complex high-pressure requirements. In this work, we present an upgraded, automated PHIP system capable of hyperpolarizing sample volumes up to 2.2 mL, which is suitable for preclinical MRI applications. We developed several high-pressure reactors and multiport NMR tube caps compatible with standard commercial 5, 10, and 16 mm glass tubes. Reactor designs were simulated and fabricated from chemically resistant polymers, ensuring mechanical safety at more than 30 bar. Using FLASH MRI, nutation, and CPMG sequences, we characterized magnetic field homogeneity and stability, establishing optimal sample dimensions (12.5/16 mm ID/OD glass tube, 20 mm height) with a
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