From bidirectional pathophysiology to integrative therapeutics: current status and future perspectives of acupuncture for tinnitus-insomnia comorbidity.

Hantong Hu, Xiaohan Huang, Yang Wang, Yang Li, Lianqiang Fang, Jie Zhou, Hong Gao

Abstract read

In one paragraph

Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hantong Hu *Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Xiaohan Huang *The Third Clinical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Yang WangDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Yang LiDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Lianqiang FangDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Jie ZhouDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Hong GaoDepartment of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This perspective article discusses the complex bidirectional relationship between tinnitus and insomnia, a prevalent and burdensome comorbidity. It synthesizes evidence suggesting the conditions mutually exacerbate one another through shared pathophysiological mechanisms, including central hyperarousal, emotional dysregulation, and aberrant neural network connectivity. Our study then explores acupuncture as a potential integrated therapy. Preliminary clinical studies indicate acupuncture can concurrently alleviate both tinnitus and insomnia symptoms. Its therapeutic potential is attributed to multi-target effects, such as regulating the autonomic nervous system and HPA axis, modulating neurotransmitters and neuroinflammation, and normalizing functional brain networks. Our study concludes by highlighting the critical need for rigorous research focusing specifically on the comorbidity to validate these mechanisms and establish clinical efficacy.

Indexed as

acupuncturebidirectional relationshipcomorbidityinsomnianeuroplasticitytinnitus

Identifiers

PMID41425820

DOI10.3389/fpsyt.2025.1688016

PMCPMC12711800

What Socratic holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.