SynthesisFrontiers in aging neuroscience2025
The effect of mind-body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aims to comprehensively analyze the effects of mind-body exercise on cognitive function, brain structure, and brain function in individuals with mild cognitive impairment (MCI) by assessing randomized controlled trials. Methods: A systematic search was conducted using four databases: Cochrane Library, EMBASE, PubMed, and Web of Science, from inception until December 2023. The study quality was assessed using the Cochrane risk-of-bias tool. Systematic review and meta-analyses were performed for outcome measures such as the Montreal Cognitive Assessment (MoCA), gray matter volume (GMV), functional connectivity at rest (rsFC), amplitude of low-frequency fluctuation (ALFF) and event-related potential (ERP) P300 latency. Three-dimensional coordinates of brain regions with notable variances were extracted from imaging and delineated in the brain map. Results: After screening 433 studies, nine met the eligibility inclusion criteria. In 4 studies using the MoCA scale, meta-analysis showed a significant effect of aerobic exercise intervention on global cognitive function improvement (MD = 1.6; 95% CI: 0.70 to 2.50; Conclusion: This systematic review demonstrates that mind-body exercise is associated with improved cognitive function and neuroplastic changes in older adults with mild cognitive impairment, with changes particularly evident in regions vulnerable to neurodegeneration such as the hippocampus and anterior cingulate cortex. Systematic review registration: CRD42022251115; https://www.crd.york.ac.uk/PROSPERO/view/CRD42022251115.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.