Evidence map›Paper›PMID 41425936›Full record

ArticleFrontiers in microbiology2025

Effects of total abdominal irradiation on gut microbiota and metabolome during acute tissue injury.

Lina Lu, Qingyu Huang, Chao Sun, Shuhe Kang, Pen Jin, Xin Wang, Xingping Luo, Jia Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Characterization of the Intestinal Metabolic Profiles Following Photon FLASH Irradiation.Dose-response : a publication of International Hormesis Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lina Lu *Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Qingyu Huang *Key Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Chao SunInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu, China.
Shuhe KangKey Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Pen JinKey Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Xin WangKey Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Xingping LuoKey Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.
Jia LiKey Laboratory of Environment-Friendly Composite Materials of the State Ethnic Affairs Commission, Gansu Provincial Biomass Function Composites Engineering Research Center, Key Laboratory for Utility of Environment-Friendly Composite Materials and Biomass in University of Gansu Province, Gansu Province Research Center for Basic Sciences of Surface and Interface Chemistry, College of Chemical Engineering, Northwest Minzu University, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Radiation-induced intestinal injury is the most common complication following radiotherapy for pelvic tumors. Effective clinical treatments remain limited, and its underlying mechanism remains unclear. Using a mouse model, this study dynamically characterizes the progression of acute radiation-induced intestinal injury through integrated analysis of the gut microbiota and metabolome, thereby supporting the development of rational therapeutic strategies. Methods: Mice received a single 12 Gy dose of total abdominal irradiation. Feces were collected for microbiota and metabolomic analysis, and intestinal tissues were harvested at 24 h and 3 days post-irradiation. These tissues underwent both histopathological assessment and analysis of inflammatory signaling pathways. Results: Total abdominal irradiation induced severe intestinal injury. At 24 h post-irradiation, intestinal mucosal cell nuclei were fragmented and intestinal permeability increased. The damage progressively worsened, and by 3 days, villi had shortened, nuclear fragmentation was more extensive, and eosinophilic granulocytes had infiltrated the tissue. Bioinformatic analysis of microbiota data revealed gut dysbiosis during the acute injury phase, characterized by reduced Conclusion: Overall, these data indicate that radiation exposure disrupts both the gut microbiota and metabolome during the acute injury phase, reducing beneficial bacteria such as

Indexed as

acute phase of injurygut microbiotametabolomeradiation-induced intestinal injuryTLR4/MYD88/NF-κB signaling pathway

Identifiers

PMID41425936
PMCPMC12714879

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.