ArticleFrontiers in cellular and infection microbiology2025
A catechol-modified quaternized chitosan/PEG hydrogel for diabetic wound healing: synergistic effects of TGF-β3 delivery, angiogenesis, and antibacterial activity.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Nanoparticulate and Hydrogel Vehicles for Stimuli-Responsive and Sustained Controlled Release of Active Pharmaceutical Ingredients.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Bio-Inspired Adhesive Hydrogels for Localized Therapeutic Delivery: From Catechol Chemistry to Smart Biointerfaces.Biomimetics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic foot ulcers (DFUs) represent a challenging chronic wound model, often plagued by biofilm formation that sustains inflammation and impedes healing. Transforming growth factor-beta 3 (TGF-β3) is a promising cytokine for tissue regeneration, yet its delivery within the hostile, infected wound milieu remains problematic. This study addresses the intertwined challenges of microbial resistance and healing impairment by developing a multifunctional injectable hydrogel that couples inherent antibacterial activity with sustained TGF-β3 release. Methods: A catechol-modified quaternized chitosan (QCS-Catechol) was synthesized and crosslinked with benzaldehyde-terminated 4-arm polyethylene glycol (4-arm PEG-CHO) to form the BP-QS/TGF-β3 hydrogel. Its physicochemical properties, injectability, adhesion, and mechanical strength were characterized. Antibacterial efficacy was evaluated against Results: The BP-QS/TGF-β3 hydrogel demonstrated rapid gelation (~3 min), excellent injectability, robust tissue adhesion (28.5 ± 2.1 J/m²), and suitable mechanical properties. It exhibited outstanding biocompatibility and potent, broad-spectrum antibacterial efficiency (>94%). The sustained release of TGF-β3 significantly enhanced fibroblast migration and proliferation Conclusions: The BP-QS/TGF-β3 hydrogel synergizes potent antibacterial action with sustained TGF-β3 delivery to disrupt the vicious cycle of biofilm infection and healing failure. This integrated, multidisciplinary strategy effectively targets the core pathology of diabetic wounds, offering a promising therapeutic platform for managing biofilm-infected chronic wounds.
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Registered trials
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