Evidence map›Paper›PMID 41425966›Full record

ArticleFrontiers in cellular and infection microbiology2025

PFKFB3 alleviates the advancement of

Yani Zhang, Yanqing Zhang, Hanfeng Tang, Jianzhang Hu

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yani Zhang *Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China.
Yanqing Zhang *Department of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China.
Hanfeng TangDepartment of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China.
Jianzhang HuDepartment of Ophthalmology, Fujian Medical University Union Hospital, Fuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the anti-inflammatory effect of glycolysis rate-limiting enzyme 6-phosphofructose-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) in fungal keratitis (FK) infected by Methods: We identified the up-regulation of PFKFB3 in fungal keratitis via western blot, quantitative real-time polymerase chain reaction (RT-PCR), and immunofluorescence staining. Subsequently, elucidated the augmentation of glycolytic flux in cornea and bone marrow-derived macrophages (BMDM) following Results: PFKFB3 was highly triggered in Conclusions: In

Indexed as

FusariosisFusariumKeratitisMacrophagesPhosphofructokinase-2AnimalsCorneaDisease Models, AnimalGlycolysisInflammationMiceMice, Inbred C57BLPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSignal TransductionTranscription Factor RelAPFKFB3 protein, mousePhosphatidylinositol 3-KinasesPhosphofructokinase-2Proto-Oncogene Proteins c-aktTranscription Factor RelABMDMFungal keratitisglycolysisinflammationPFKFB3

Identifiers

PMID41425966
PMCPMC12711700

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.