ReviewFrontiers in cardiovascular medicine2025
Association between constipation and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.
Review in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate the association between constipation and risk of coronary heart disease (CHD). Methods: We systematically searched PubMed, Web of Science, and Cochrane Library until 28 February 2025. Published cohort studies reporting quantitative association measures for CHD in constipated vs. non-constipated individuals were included. The heterogeneity was assessed via the chi-square test based on Cochrane Q statistics. Results: Nine studies involving 283,070 constipation cases and 3,343,120 controls were analyzed. Constipation was associated with a 10% increased CHD risk [hazard ratio (HR] = ).10, 95% confidence interval (CI): 1.05-1.15]. Statistical heterogeneity ( Conclusion: Our meta-analysis identified a significant positive association between constipation and CHD risk, particularly myocardial infarction. These findings suggest that constipation may either accelerate the pathological processes underlying CHD or that both conditions share common etiological pathways, warranting further mechanistic and interventional studies.
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