Evidence map›Paper›PMID 41426431›Full record

ArticleBrain communications2025

Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank.

Denise Wezel, Olivier Parent, Manuela Costantino, Lina Sifi, Grace Pigeau, Nicole J Gervais, Ann McQuarrie, Josefina Maranzano, Gabriel A Devenyi, Mahsa Dadar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denise WezelCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.ORCID https://orcid.org/0009-0004-9865-544X
Olivier ParentCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-3177-0353
Manuela CostantinoDepartment of Genetic Medicine, University of Chicago, 60637 Chicago, IL, USA.
Lina SifiCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.
Grace PigeauCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.
Nicole J GervaisGroningen Institute for Evolutionary Life Sciences, Faculty of Science and Engineering, Rijksuniversiteit Groningen, 9712 CP Groningen, The Netherlands.
Ann McQuarrieFaculty of Anatomy and Cell Biology, McGill University, H3A 0C7 Montreal, QC, Canada.
Josefina MaranzanoFaculty of Medicine, McGill University, H3G 2M1 Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-9696-5522
Gabriel A DevenyiCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.ORCID https://orcid.org/0000-0002-7766-1187
Mahsa DadarCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.
M Mallar ChakravartyCerebral Imaging Center, Douglas Mental Health University Institute, H4H 1R3 Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White matter hyperintensities (WMHs) are radiological abnormalities indicative of cerebrovascular dysfunction associated with increased risk for cognitive decline. WMHs increase in prevalence with older age, and there are known sex differences as older women harbour higher WMH burden than men. Some have hypothesized that the increase in this dementia-related risk factor is related to the menopausal transition. To untangle the effects of age and menopause, we leveraged a large cross-sectional sample of women from the UK Biobank (

Indexed as

brain agingcardiometabolic risk factorsmenopausewhite matter hyperintensities

Identifiers

PMID41426431
PMCPMC12715771

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.