Non-linear association of the alanine aminotransferase to high-density lipoprotein cholesterol ratio with non-alcoholic fatty liver disease: a secondary analysis of a Chinese cohort.

Background: Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a major public health concern, with rising prevalence worldwide. The alanine aminotransferase to high-density lipoprotein cholesterol (ALT/HDL-C) ratio has emerged as a potential marker of metabolic dysfunction, but its association with NAFLD remains underexplored, particularly in Chinese populations. This study aimed to investigate the independent and nonlinear association between the ALT/HDL-C ratio and NAFLD in Chinese adults. Methods: This was a secondary analysis of a cross-sectional dataset. A total of 1,592 Chinese adults aged 40-70 years who underwent health checkups were included. NAFLD was diagnosed via abdominal ultrasound. The ALT/HDL-C ratio was calculated and analyzed as both a continuous and categorical variable (tertiles). Multivariable logistic regression, restricted cubic spline (RCS) analysis, and receiver operating characteristic curves were used to assess the association and predictive performance of the ALT/HDL-C ratio for NAFLD. Results: The prevalence of NAFLD was 61.1%. After full adjustment, each one standard deviation increase in the ALT/HDL-C ratio was associated with a 79% higher odds of NAFLD (odds ratio [OR] = 1.79, 95% CI: 1.39-2.31, Conclusion: The ALT/HDL-C ratio is independently and nonlinearly associated with NAFLD in Chinese adults, with a particularly strong association in non-elderly individuals and women. This simple and readily available biomarker shows promise for enhancing NAFLD risk stratification in middle-aged adults, while its utility in the elderly population may be limited and requires further investigation.