Evidence map›Paper›PMID 41426967›Full record

ArticleSovremennye tekhnologii v meditsine2025

Measurable Metrics of Mesenchymal Stem Cell Aging.

D A Kalashnikova, S E Romanov, D A Maksimov, I A Plokhikh, R Yu Epifanov, R I Mullyadjanov, L O Sidelnikov, P A Antoshina, Ya A Osipov, V V Shloma and 4 more

Abstract read
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In one paragraph

Article in Sovremennye tekhnologii v meditsine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

D A KalashnikovaJunior Researcher, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Junior Researcher, Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
S E RomanovPhD, Researcher, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Researcher, Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
D A MaksimovPhD, Senior Researcher, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Researcher, Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
I A PlokhikhJunior Researcher, Laboratory of Applied Digital Technologies; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia.
R Yu EpifanovJunior Researcher, Laboratory of Applied Digital Technologies; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia.
R I MullyadjanovDSc, Head of the Laboratory of Applied Digital Technologies; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Head of the Laboratory of Supercomputing and Artificial Intelligence in Power Engineering; Kutateladze Institute of Thermophysics of the Siberian Branch of the Russian Academy of Sciences, 1 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
L O SidelnikovResearch Assistant, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia.
P A AntoshinaJunior Researcher, Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
Ya A OsipovResearch Assistant, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia.
V V ShlomaPhD, Head of the Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.
A A BudilinaResearch Assistant, Laboratory of Molecular Mechanisms of Regeneration and Aging; Engelgard Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilova St., Moscow, 119991, Russia; Junior Researcher, Laboratory of Regenerative Medicine; Research Institute of Pulmonology of Federal Medico-Biological Agency of Russia, 28, Bldg. 10, Orekhoviy Blvd., Moscow, 115682, Russia.
E M SamoylovaJunior Researcher, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Junior Researcher, Laboratory of Molecular Mechanisms of Regeneration and Aging; Engelgard Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilova St., Moscow, 119991, Russia.
V P BaklaushevMD, DSc, Head of the Laboratory of Molecular Mechanisms of Regeneration and Aging; Engelgard Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilova St., Moscow, 119991, Russia; Head of the Laboratory of Regenerative Medicine; Research Institute of Pulmonology of Federal Medico-Biological Agency of Russia, 28, Bldg. 10, Orekhoviy Blvd., Moscow, 115682, Russia; Chief of the Center for Biomedical Research; Federal Scientific Clinical Center for Specialized Types of Medical Care and Medical Technologies of the Federal Medico-Biological Agency of Russia, 28, Bldg. 1-9, Orekhoviy Blvd., Moscow, 115682, Russia; Head of the Department of Cellular Preparation Development; Federal Center of Brain Research and Neurotechnologies of the Federal Medico-Biological Agency of Russia, 1, Bldg. 10, Ostrovityanova St., Moscow, 117513, Russia.
P P LaktionovPhD, Senior Researcher, Laboratory of Epigenetics; Novosibirsk National Research State University, 1 Pirogova St., Novosibirsk, 630090, Russia; Senior Researcher, Laboratory of Genomics; Institute of Molecular and Cellular Biology of the Siberian Branch of the Russian Academy of Sciences, 8/2 Acad. Lavrentiev Avenue, Novosibirsk, 630090, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Materials and Methods: In the study, the dynamics of expression of individual genes encoding key regulators of cellular aging across various models of cellular senescence, as well as telomere length were investigated by real-time PCR. The analysis of the high- throughput transcriptome sequencing datasets of mesenchymal stem cells from the donors of different ages has been performed. Using regression methods, predictive models based on transcriptomic data were developed to estimate chronological age and the duration of Results:

Indexed as

Cellular SenescenceMesenchymal Stem CellsAdultCells, CulturedHumansTranscriptomecell senescenceexpressionmesenchymal stem cellspredictive models for senescence assessmentstelomeres

Identifiers

PMID41426967
PMCPMC12715488

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.