ReviewFrontiers in neurology2025
Relationship between selenium intake, circulating selenium levels, and stroke: a systematic review and meta-analysis.
Review in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ischemic stroke represents the most prevalent form of cerebrovascular disease, which has a significant impact on people's quality of life. Selenium is a crucial trace mineral with potential relevance for the prevention of cerebrovascular disease due to its antioxidant properties. Recent research has increasingly linked circulating selenium levels to the incidence of ischemic stroke, however, the findings remained inconsistent. The primary objective of our meta-analysis is to explore the potential relationship between circulating selenium levels and stroke as well as stroke mortality. In the meantime, the current study was done to evaluate the influence of dietary selenium intake on the risk of stroke. Methods: A comprehensive systematic search of electronic databases was conducted from inception through April 11, 2025, to identify relevant studies investigating the associations between circulating selenium levels, dietary selenium intake and ischemic stroke risk. Ultimately, 26 eligible studies were included in the meta-analysis. Results: (1) The aggregated weighted mean difference (WMD) demonstrated that circulating selenium concentrations were markedly reduced in the ischemic stroke cohort relative to the control cohort (WMD = -0.13 [-0.20, -0.07]). (2) The multivariable-adjusted relative risk (RR) indicated that increased circulating selenium levels linked to a notable decrease in the risk of ischemic stroke (RR = 0.88 [0.83,0.92]), as well as a decreased risk of stroke mortality (RR = 0.86 [0.80, 0.93]). (3) Furthermore, our meta-analysis found that increased dietary selenium intake was adversely correlated with the risk of stroke, with RR of 0.87(0.76, 0.99). (4) A meta-analysis of dose-response curves revealed that circulating selenium levels were adversely linked with stroke. Conclusion: The level of circulation selenium is lower in ischemic stroke patients. There was an inverse association between the level of circulation selenium and the incidence of ischemic stroke as well as stroke mortality. Meanwhile, higher dietary selenium intake were shown to be negatively associated with ischemic stroke.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.