Evidence map›Paper›PMID 41427004›Full record

ArticleAnalytical cellular pathology (Amsterdam)2025

Prognostic Value of UBE2S, HIF-1α, and FOXM1 Expression in Esophageal Squamous Cell Carcinoma.

Wan Li, Keming Zhou, Mengyan Li, Liping Su, Xianwen Liu, Yuanyuan Lv, Yuqing Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wan LiDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Keming ZhouDepartment of Hypertension Center, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, Key Laboratory of Xinjiang Uygur Autonomous Region Hypertension Research Laboratory, NHC Key Laboratory of Hypertension Clinical Research, Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Urumqi, Xinjiang, China, xjrmyy.com.
Mengyan LiDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Liping SuDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Xianwen LiuDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Yuanyuan LvDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.
Yuqing MaDepartment of Pathology, The First Affiliated Hospital, Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, Xinjiang, China, xjmu.edu.cn.ORCID https://orcid.org/0000-0001-8009-4358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The present investigation was aimed to examine ubiquitin-conjugating enzyme E2S (UBE2S), hypoxia-inducible factor (HIF)-1α, and factor forkhead box M1 (FOXM1) levels in esophageal squamous cell carcinoma (ESCC) and esophageal low-grade intraepithelial neoplasia (LIN), high-grade intraepithelial neoplasia (HIN). Additionally, the investigation explored the correlation between these levels and clinicopathological features in addition to prognosis. Methods: To investigate the expression patterns of UBE2S, HIF-1α, and FOXM1, immunohistochemical staining was performed on tissue samples, including LIN, HIN, ESCC, and healthy controls. Subsequently, the chi-square test was applied to analyze the correlations between the expression levels of the three proteins and the clinicopathological features of ESCC. The impact of UBE2S, HIF-1α, and FOXM1 on ESCC prognosis was evaluated using survival analysis. Spearman correlation analysis was employed to analyze the correlation of three proteins in ESCC, HIN, and LIN, respectively. Results: UBE2S overexpression was related to ethnicity ( Conclusion: The expression levels of UBE2S, HIF-1α, and FOXM1 are closely associated with the incidence and progression of ESCC. UBE2S, HIF-1α, and FOXM1 have potential as prognostic indicators for ESCC.

Indexed as

Esophageal NeoplasmsEsophageal Squamous Cell CarcinomaForkhead Box Protein M1Hypoxia-Inducible Factor 1, alpha SubunitUbiquitin-Conjugating EnzymesAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorForkhead Box Protein M1FOXM1 protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitUbe2S protein, humanUbiquitin-Conjugating Enzymesesophageal intraepithelial neoplasiaesophageal squamous cell carcinomaFOXM1HIF-1αprognosisUBE2S

Identifiers

PMID41427004
PMCPMC12717677

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.